Automated subfield volumetric analysis of hippocampus in temporal lobe epilepsy using high-resolution T2-weighed MR imaging.
Automated subfield volumetric analysis of hippocampus in temporal lobe epilepsy using high-resolution T2-weighed MR imaging.
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DOI：
10.1016/j.nicl.2016.06.008
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Matsuda H
中科院分区：
文献类型：
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作者：
Sone D;Sato N;Maikusa N;Ota M;Sumida K;Yokoyama K;Kimura Y;Imabayashi E;Watanabe Y;Watanabe M;Okazaki M;Onuma T;Matsuda H
海马的自动子域体积测定法用于颞叶癫痫（TLE）是理想的，但其效用尚未建立。海马子场（ASHS）的自动分割和使用高分辨率T2加权MR成像的FreeSurfer软件（版本6.0）的新版本是该体积测定的候选者。本研究的目的是使用ASHS以及旧版本和新版本的FreeSurfer评估TLE患者的海马子区域。我们招募了50名连续的单侧TLE患者，其中25名患有海马硬化症（TLE-HS），25名无明显病因（TLE-nonHS）。所有患者和45名健康对照者均行高分辨率T2加权和三维容积T1加权MRI扫描。我们使用FreeSurfer ver.5.3、ver.6.0和ASHS分析了所有患者的MR图像。对于每个子场，计算标准化z评分，并在组间进行比较。在TLE-HS组中，ASHS和FreeSurfer版本6.0显示同侧角氨（CA）1、CA 4和齿状回（DG）的z评分最大，而FreeSurfer版本5.3显示同侧下托的z评分最大。在TLE-nonHS组中，ASHS或FreeSurfer均未显著减少体积。与旧版FreeSurfer（版本5.3）相比，ASHS和新版FreeSurfer在与HS TLE患者现有组织病理学知识的兼容性方面可能具有优势，尽管需要进一步研究病理学结果和/或手术结局。颞叶癫痫（TLE）需要自动海马子场分析。自动分割海马子字段（ASHS）和FreeSurfer可用。分析了50例TLE患者（25例伴有海马硬化（HS））。ASHS和FreeSurfer的新版本可能在兼容性方面具有优势。高分辨率T2加权图像可能有助于更好地自动分割TLE。
Automated subfield volumetry of hippocampus is desirable for use in temporal lobe epilepsy (TLE), but its utility has not been established. Automatic segmentation of hippocampal subfields (ASHS) and the new version of FreeSurfer software (ver.6.0) using high-resolution T2-weighted MR imaging are candidates for this volumetry. The aim of this study was to evaluate hippocampal subfields in TLE patients using ASHS as well as the old and new versions of FreeSurfer. We recruited 50 consecutive unilateral TLE patients including 25 with hippocampal sclerosis (TLE-HS) and 25 without obvious etiology (TLE-nonHS). All patients and 45 healthy controls underwent high-resolution T2-weighted and 3D-volume T1-weighted MRI scanning. We analyzed all of their MR images by FreeSurfer ver.5.3, ver.6.0 and ASHS. For each subfield, normalized z-scores were calculated and compared among groups. In TLE-HS groups, ASHS and FreeSurfer ver.6.0 revealed maximal z-scores in ipsilateral cornu ammonis (CA) 1, CA4 and dentate gyrus (DG), whereas in FreeSurfer ver.5.3 ipsilateral subiculum showed maximal z-scores. In TLE-nonHS group, there was no significant volume reduction by either ASHS or FreeSurfer. ASHS and the new version of FreeSurfer may have an advantage in compatibility with existing histopathological knowledge in TLE patients with HS compared to the old version of FreeSurfer (ver.5.3), although further investigations with pathological findings and/or surgical outcomes are desirable. Automated hippocampal subfield analysis is needed in temporal lobe epilepsy (TLE). Automatic segmentation hippocampal subfields (ASHS) and FreeSurfer are available. 50 TLE patients (25 with hippocampal sclerosis (HS)) were analyzed. ASHS and new version of FreeSurfer may have an advantage in compatibility. High-resolution T2-weighted images might help better automatic segmentation in TLE.