Dietary patterns associated with colon and rectal cancer:: results from the Dietary Patterns and Cancer (DIETSCAN) Project
Dietary patterns associated with colon and rectal cancer:: results from the Dietary Patterns and Cancer (DIETSCAN) Project
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DOI：
10.1093/ajcn/80.4.1003
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发表时间：
2004-10-01
影响因子：
7.1
通讯作者：
Goldbohm, RA
中科院分区：
文献类型：
--
作者：
Dixon, LB;Balder, HF;Goldbohm, RA
背景资料：对饮食模式或食物组合的分析可以提供关于饮食对结肠癌和直肠癌风险的影响的见解。目的：饮食模式与癌症的主要目的（DIETSCAN）项目旨在开发和应用一种通用的方法学方法来研究4个欧洲队列的饮食模式和癌症：α-生育酚β-胡萝卜素预防癌症研究（芬兰-ATBC）、荷兰饮食与癌症队列研究（NLCS）、瑞典乳腺X线摄影队列研究（SMC）、和Ormoni e Dieta nella Eziologia dei Tumori（意大利-ORDET）。三个队列（ATBC，NLCS和SMC）提供的数据，结肠和直肠癌为本study.Design：队列建立于1985年和1992年之间，随访数据来自国家癌症登记处。参与者完成验证半定量的食物频率调查问卷在baseline.Results：探索性因素分析，在每个队列进行，确定3-5个稳定的饮食模式。两种饮食模式-蔬菜和猪肉，加工肉类，土豆（PPP）-在所有队列中都很常见。校正潜在混杂因素后，PPP与SMC女性结肠癌风险增加相关（五分位数4（多相关）风险：1.62;95%CI：1.12，2.34;趋势P = 0.01）。PPP也与ATBC男性直肠癌风险增加相关（五分位数4（多相关）风险：2.21; 95% CI：1.07，4.57;趋势P = 0.05）。这两种模式都与结肠癌或直肠癌的风险在NLCS的妇女和mes.Conclusion：虽然某些饮食模式可能是一致的，在整个欧洲国家，这些饮食模式和结肠癌和直肠癌的风险之间的关联是不确定的。
Background: An analysis of dietary patterns or combinations of foods may provide insight regarding the influence of diet on the risk of colon and rectal cancer.Objective: A primary aim of the Dietary Patterns and Cancer (DIETSCAN) Project was to develop and apply a common methodologic approach to study dietary patterns and cancer in 4 European cohorts: the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study (Finland-ATBC), the Netherlands Cohort Study (NLCS) on Diet and Cancer, the Swedish Mammography Cohort (SMC), and the Ormoni e Dieta nella Eziologia dei Tumori (Italy-ORDET). Three cohorts (ATBC, NLCS, and SMC) provided data on colon and rectal cancer for the present study.Design: The cohorts were established between 1985 and 1992; follow-up data were obtained from national cancer registries. The participants completed validated semiquantitative food-frequency questionnaires at baseline.Results: Exploratory factor analysis, conducted within each cohort, identified 3-5 stable dietary patterns. Two dietary patterns-Vegetables and Pork, Processed Meats, Potatoes (PPP)-were common across all cohorts. After adjustment for potential confounders, PPP was associated with an increased risk of colon cancer in the SMC women (quintile 4(multirelative) risk: 1.62;95%CI: 1.12, 2.34; P for trend = 0.01). PPP was also associated with an increased risk of rectal cancer in the ATBC men (quintile 4(multirelative) risk: 2.21; 95% Cl: 1.07, 4.57; P for trend = 0.05). Neither pattern was associated with the risk of colon or rectal cancer in the NLCS women and men.Conclusion: Although certain dietary patterns may be consistent across European countries, associations between these dietary patterns and the risk of colon and rectal cancer are not conclusive.