Cell death ky apoptosis: Basic concepts and disease relevance for the gastroenterologist
Cell death ky apoptosis: Basic concepts and disease relevance for the gastroenterologist
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DOI：
10.1053/gast.1996.v110.pm8613014
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发表时间：
1996-04-01
期刊：
影响因子：
29.4
通讯作者：
Gores, GJ
中科院分区：
文献类型：
--
作者：
Que, FG;Gores, GJ
我们以概念性的方式和适当的科学细节回顾了细胞凋亡在胃肠道疾病中所起的作用。这些信息应该有助于临床医生和临床研究人员更好地了解和治疗胃肠道疾病。未来对细胞凋亡的研究可能会进一步深入了解调控细胞凋亡的细胞信号级联反应，Bcl2抑制细胞凋亡的机制(S)，以及细胞凋亡在肿瘤发生、促进和发展中的确切作用。我们预计，在未来，执业胃肠病医生将有可用的治疗策略来抑制与细胞死亡相关的各种胃肠道疾病的细胞凋亡，并诱导细胞凋亡用于胃肠道肿瘤的治疗。(胃肠病学1996年4月110(4)：1238-43)
We have reviewed in a conceptual manner with appropriate scientific detail the role apoptosis plays in diseases of the gastrointestinal tract. This information should help the clinician and clinician investigator to better understand and treat gastrointestinal diseases. Future investigations in apoptosis probably will provide further insight into the cell-signaling cascades regulating apoptosis, the mechanism(s) by which Bcl-2 inhibits apoptosis, and the precise role of apoptosis in cancer initiation, promotion, and progression. We anticipate that in the future, the practicing gastroenterologist will have therapeutic strategies available to inhibit apoptosis for various gastrointestinal diseases associated with cell death and to induce apoptosis for the treatment of gastrointestinal neoplasia. (Gastroenterology 1996 Apr;110(4):1238-43)