Radiation detector developments in medical applications: inorganic scintillators in positron emission tomography.
Radiation detector developments in medical applications: inorganic scintillators in positron emission tomography.
复制标题
辐射探测器在医疗应用中的发展：正电子发射断层扫描中的无机闪烁体。
DOI：
10.1093/rpd/ncn043
复制
发表时间：
2008
影响因子：
1
通讯作者：
C. van Eijk
中科院分区：
文献类型：
--
作者：
C. van Eijk
近年来，许多新型伽马射线闪烁体已投入商业使用。这些闪烁体要么源自已知的闪烁体，例如闪烁体。 LuAlO3:Ce 中的 Lu1-xYxAlO3: Ce (LuYAP) 和 Lu2SiO5:Ce 中的 Lu(2(1-x))Y2xSiO5:Ce (LYSO) 或者是新发现的结果，例如LaCl3:Ce 和 LaBr3:Ce。前两种材料主要由于相对较高的检测效率和快速响应而受到关注； LYSO 已在飞行时间 (TOF) 正电子发射断层扫描 (TOF PET) 中得到应用，而 LuYAP-LYSO 组合则用于小动物 PET。卤化物闪烁体在 662 keV 下具有约 3% 的出色能量分辨率，并且具有相对较高的光输出。 LaBr3:Ce 正在研究在 TOF PET 中的应用。与此同时，新型闪烁体材料的寻找和研究也在不断进行。例如，LuI3:Ce是一种具有非常高光产量（大约90,000光子MeV(-1)）的新材料。新材料的其他例子是(C6H13NH3)2PbI4和(C3H7NH3)2PbBr4，有机-无机杂化化合物，其中前者具有非常快的亚纳秒响应。新型闪烁体为医疗应用（特别是 PET 系统）的新发展展现了巨大的前景。
In recent years, a number of new gamma-ray scintillators are commercially available. These scintillators are either derived from known scintillators, e.g. Lu1-xYxAlO3: Ce (LuYAP) from LuAlO3:Ce and Lu(2(1-x))Y2xSiO5:Ce (LYSO) from Lu2SiO5:Ce or are the result of new discoveries, e.g. LaCl3:Ce and LaBr3:Ce. The first two materials are primarily of interest because of the relatively high detection efficiency and fast response; LYSO has found application in time-of-flight (TOF) positron-emission tomography (TOF PET) and the LuYAP-LYSO combination is used in small-animal PET. The halide scintillators have an excellent energy resolution of approximately 3% at 662 keV and they have a relatively high light yield. LaBr3:Ce is being studied for application in TOF PET. At the same time, the search for and research on new scintillator materials are going on. For example, LuI3:Ce is a new material with a very high light yield (approximately 90,000 photons MeV(-1)). Other examples of new materials are (C6H13NH3)2PbI4 and (C3H7NH3)2PbBr4, organic-inorganic hybrid compounds, of which the former has a very fast sub-nanosecond response. The new scintillators show great promise for new developments in medical applications, in particular, for PET systems.