Transplacental transmission of SARS-CoV-2 infection
Transplacental transmission of SARS-CoV-2 infection
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DOI：
10.1038/s41467-020-17436-6
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发表时间：
2020-07-14
影响因子：
16.6
通讯作者：
De Luca, Daniele
中科院分区：
文献类型：
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作者：
Vivanti, Alexandre J.;Vauloup-Fellous, Christelle;De Luca, Daniele
SARS-CoV-2疫情是本世纪的第一次大流行。SARS-CoV-2感染是通过飞沫传播的；其他传播途径是假设的，但没有得到证实。到目前为止，还不清楚SARS-CoV-2能否以及如何从母亲传播给胎儿。我们展示了SARS-CoV-2通过胎盘的传播，其新生儿的母亲在最后三个月感染了SARS-CoV-2，并出现神经损害。通过全面的病毒学和病理学调查证实了这种传播。具体来说，SARS-CoV-2引起：(1)母体病毒血症；(2)免疫组织化学显示的胎盘感染和非常高的病毒载量；(3)胎盘感染后的新生儿病毒血症。对新生儿进行临床研究、影像检查和随访。新生儿表现为神经系统症状，与成人患者的症状相似。SARS-CoV-2的先天性感染已被描述，但其传播途径尚不清楚。在这里，作者报告了SARS-CoV-2通过胎盘传播的证据，该新生儿的母亲在最后三个月感染了SARS-CoV-2，并出现了神经损害。
SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients. Congenital infection of SARS-CoV-2 has been described, but the transmission routes remain unclear. Here, the authors report evidence of transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise.