Impairment on the hippocampal-dependent virtual Morris water task in schizophrenia
Impairment on the hippocampal-dependent virtual Morris water task in schizophrenia
复制标题
DOI：
10.1016/j.schres.2006.05.021
复制
发表时间：
2006-10-01
影响因子：
4.5
通讯作者：
Canive, Jose M.
中科院分区：
文献类型：
--
作者：
Hanlon, Faith M.;Weisend, Michael P.;Canive, Jose M.
传统的视觉和言语记忆的神经心理学测试已被用于评估精神分裂症的记忆缺陷。然而，这些测试不能用于非人类动物研究，这对于发现改善认知的治疗方法和研究精神分裂症的病因很重要。为了帮助弥合人类和非人类动物对精神分裂症海马功能研究之间的差距，本研究试图描述患者使用Morris水任务（MWT）表现出的行为表现。在人类和非人类动物研究中，MWT已显示出对海马的依赖性。在虚拟MWT中，人类主体通过定位平台来导航计算机生成的屏幕环境以逃离“水”。精神分裂症患者和对照组进行了两个版本的虚拟MWT：一个海马依赖的隐藏平台版本，依赖于allocentric导航能力，和一个非海马依赖的可见平台版本，依赖于线索导航能力。患者走得更远，需要更长的时间才能在训练块上找到隐藏的平台，并且在探测试验期间在正确的象限中花费的时间更少。在可见平台条件下没有缺陷。这些研究结果确定了精神分裂症和支持使用MWT在精神分裂症的动物模型测试依赖于任务的行为障碍。(c)2006 Elsevier B.V.保留所有权利。
Traditional neuropsychological tests of visual and verbal memory have been used to evaluate memory deficits in schizophrenia. However, these tests cannot be used in non-human animal research, which is important for the discovery of treatments that will improve cognition and for study of the etiology of schizophrenia. To help bridge the gap between human and non-human animal research on hippocampal function in schizophrenia, this study sought to characterize the behavioral performance exhibited by patients using the Morris water task (MWT). The MWT has been shown in human and non-human animal studies to be hippocampus-dependent. In the virtual MWT, human subjects navigate a computer-generated on-screen environment to escape from the "water" by locating a platform. Patients with schizophrenia and controls performed two versions of the virtual MWT: a hippocampal-dependent hidden-platform version, relying on allocentric navigational abilities, and a non-hippocampal-dependent visible-platform version, relying on cued-navigational abilities. Patients traveled further and took longer to find the hidden platform over training blocks and spent less time in the correct quadrant during a probe trial. There was no deficit in the visible-platform condition. These findings identify a behavioral impairment on a hippocampal-dependent task in schizophrenia and support using the MWT in testing animal models of schizophrenia. (c) 2006 Elsevier B.V. All rights reserved.