Congenital renal agenesis: Case-control analysis of birth characteristics
Congenital renal agenesis: Case-control analysis of birth characteristics
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DOI：
10.1053/ajkd.2002.31982
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发表时间：
2002-04-01
影响因子：
13.2
通讯作者：
Schrier, RW
中科院分区：
文献类型：
--
作者：
Parikh, CR;McCall, D;Schrier, RW
肾发育不全（RA）是最常见的先天性泌尿系统畸形，然而，产前因素与这种情况的发展的证据是有限的。本研究的目的是确定产前和围产期因素与RA的发展。我们对1989年至1998年科罗拉多州出生的RA患者进行了一项病例对照研究，该研究是在科罗拉多州对特殊需要儿童的反应中确定的，并与出生证明数据相关联。研究中有189名患有RA的婴儿和940名没有RA的对照婴儿。类风湿关节炎的发病率约为每2，900名新生儿1例。76例（40.6%）为女婴，111例（59.4%）为男婴（P = 0.02）。在控制了母亲年龄、种族和酒精暴露的情况下，母亲先前存在的糖尿病是与RA相关的重要因素（校正比值比（OR）为4.98; 95%置信区间（CI）为1.08 - 22.93）。在控制其他因素的同时，黑人母亲种族也与RA的发展显著相关（调整后的OR，2.19; 95%CI，1.26至3.95）。母亲年龄小于18岁、母亲受教育年限小于12年、母亲饮酒、婴儿性别对分娩有显著影响。RA是一种相对常见的先天性泌尿道畸形。这种情况似乎有一个多因素的原因，遗传和环境因素的组合。需要进一步的研究来更好地了解这些风险因素。(C)2002年，美国国家肾脏基金会（National Kidney Foundation，Inc.）
Renal agenesis (RA) is the most common congenital urinary malformation; however, evidence for prenatal factors associated with the development of this condition Is limited. The aim of this study is to determine prenatal and perinatal factors associated with the development of RA. We performed a case-control study of Colorado births with RA from 1989 to 1998 identified in the Colorado Responds for Children With Special Needs and linked with birth certificate data. There were 189 infants with RA and 940 control infants without RA on the study. The incidence of RA is approximately 1 per 2,900 births. Seventy-six infants (40.6%) born with RA were girls, and 111 infants (59.4%) were boys (P = 0.02). Preexisting diabetes mellitus in the mother was a significant factor associated with RA (adjusted odds ratio (OR), 4.98; 95% confidence interval (CI), 1.08 to 22.93) while controlling for maternal age, maternal race, and alcohol exposure. Black maternal race also was significantly associated with the development of RA (adjusted OR, 2.19; 95% Cl, 1.26 to 3.95) while controlling for other factors. Maternal age younger than 18 years, maternal education less than 12 years, alcohol exposure, and Infant sex approached significance. RA is a relatively common congenital malformation of the urinary tract. This condition appears to have a multifactorial cause, with a combination of genetic and environmental factors. Further research is needed to show a better understanding of these risk factors. (C) 2002 by the National Kidney Foundation, Inc.