Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism
Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism
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DOI：
10.3174/ajnr.a1790
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发表时间：
2010-01-01
影响因子：
3.5
通讯作者：
Sailasuta, N.
中科院分区：
文献类型：
--
作者：
Ross, B. D.;Bhattacharya, P.;Sailasuta, N.
超极化是一种在磁场中增强原子核居群自旋极化差的方法的总称。不少于5种不同的技术（动态核极化[DNP]；对氢诱导极化-对氢和合成允许显著增强核对准[PHIP-PASADENA]；氙/氦极化转移；Brute Force； H-1超极化水）目前正在进行彻底的研究，作为放大传统MR神经成像和光谱学中使用的固有（百万分之几）弱信号强度的手段。体内HD-MR成像是一种代谢成像工具，引起了人们对HD-MR成像的极大兴趣。迄今为止最成功的是DNIF，其中碳-13 （C-13）丙酮酸显示出许多。具有C-13琥珀酸盐的PHIP-PASADENA在几种类型的小鼠体内显示出HD-MR代谢，进入krebs -三羧酸循环，通过C-13 MR成像，MR光谱和化学位移成像进行超快检测。我们将讨论5个有前景的临床前研究：C-13琥珀酸盐PHIP在脑肿瘤中的作用；C-13乙基丙酮酸DNP和C-13醋酸酯；啮齿动物脑内DNP；C-13琥珀酸盐PHIP与脑卒中的钆显像和H-1超偏振成像。临床C-13神经光谱学的最新发展鼓励我们克服临床HD-MR成像的剩余障碍。
Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarization - parahydrogen and synthesis allow dramatically enhanced nuclear alignment [PHIP-PASADENA]; xenon/helium polarization transfer; Brute Force; H-1 hyperpolarized water) are currently under exhaustive investigation as means of amplifying the intrinsically (a few parts per million) weak signal intensity used in conventional MR neuroimaging and spectroscopy. HD-MR imaging in vivo is a metabolic imaging tool causing much of the interest in HD-MR imaging. The most successful to date has been DNIF, in which carbon-13 (C-13) pyruvic acid has shown many. PHIP-PASADENA with C-13 succinate has shown HD-MR metabolism in vivo in turner-bearing mice of several types, entering the Krebs-tricarboxylic acid cycle for ultrafast detection with C-13 MR imaging, MR spectroscopy, and chemical shift imaging. We will discuss 5 promising preclinical studies: C-13 succinate PHIP in brain tumor; C-13 ethylpyruvate DNP and C-13 acetate; DNP in rodent brain; C-13 succinate PHIP versus gadolinium imaging of stroke; and H-1 hyperpolarized imaging. Recent developments in clinical C-13 neurospectroscopy encourage us to overcome the remaining barriers to clinical HD-MR imaging.