Multimodality Imaging Features of Immunoglobulin G4-related Vessel Involvement.
Multimodality Imaging Features of Immunoglobulin G4-related Vessel Involvement.
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免疫球蛋白 G4 相关血管受累的多模态成像特征。
DOI：
10.1148/ryct.230105
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Hedgire,SandeepS
中科院分区：
文献类型：
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作者：
O'Shea,Aileen;Crotty,RoryK;Randhawa,MangunKaur;Oliveira,George;Perugino,CoryA;Stone,JohnH;Harisinghani,MukeshG;Wallace,ZacharyS;Hedgire,SandeepS
免疫球蛋白4 （IgG4）相关疾病是一种慢性免疫介导的纤维炎性疾病。包括大、中型血管在内的血管系统的介入越来越被认识到。血管受累的不同表现反映了慢性炎症和纤维化的后遗症，包括主动脉炎和动脉周炎，并伴有动脉瘤形成和夹层等并发症。当已知或怀疑其他部位有igg4相关疾病时，应考虑igg4相关大血管受累的诊断。igg4相关疾病通常影响的其他器官包括泪腺和唾液腺、甲状腺、胰腺、胆道、肺、肾脏和脑膜。诊断通常需要仔细结合临床、影像学、血清和病理结果。如果需要，患者可以使用皮质类固醇治疗或抗cd20单克隆抗体利妥昔单抗。本文讨论了大血管受累的不同临床表现和影像学特征。关键词：血管，炎症，主动脉，igg4相关血管受累©RSNA， 2024
Immunoglobulin 4 (IgG4)–related disease is a chronic immune-mediated fibroinflammatory disorder. Involvement of the vascular system, including large- and medium-sized vessels, is increasingly recognized. The varied appearances of vascular involvement reflect the sequela of chronic inflammation and fibrosis and can include aortitis and periaortitis with resultant complications such as aneurysm formation and dissection. A diagnosis of IgG4–related large vessel involvement should be considered when there is known or suspected IgG4-related disease elsewhere. Other organs that are typically affected in IgG4-related disease include the lacrimal and salivary glands, thyroid, pancreas, biliary tree, lungs, kidneys, and meninges. Diagnosis typically requires careful correlation with clinical, imaging, serum, and pathologic findings. Patients may be managed with corticosteroid therapy or the anti-CD20 monoclonal antibody, rituximab, if needed. The varied clinical presentations and imaging features of large vessel involvement are discussed herein.Keywords:Vascular, Inflammation, Aorta, IgG4-related Vessel Involvement© RSNA, 2024