How do antidepressants work? New perspectives for refining future treatment approaches.
How do antidepressants work? New perspectives for refining future treatment approaches.
复制标题
DOI：
10.1016/s2215-0366(17)30015-9
复制
发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Cowen PJ
中科院分区：
文献类型：
--
作者：
Harmer CJ;Duman RS;Cowen PJ
大多数目前可用的抗抑郁药靶向单胺神经递质功能。然而，一个纯粹的神经递质为基础的解释抗抑郁药物的作用是挑战的延迟临床发作的大多数代理和需要解释如何神经化学变化逆转抑郁症的许多不同的症状。了解抗抑郁药物作用的新方法包括关注情绪和社会处理的早期变化以及神经可塑性的作用。在这篇评论中，我们讨论了这两种不同理论反映不同或互补方法的方式，以及如何将它们整合起来，为抑郁症患者提供新的解决方案。我们考虑了这些机制方法对抑郁症新疗法的分层和开发所做的预测，以及为促进科学向临床的转化而需要采取的下一步措施。
Most currently available antidepressants target monoamine neurotransmitter function. However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of most agents and the need to explain how neurochemical changes reverse the many different symptoms of depression. Novel approaches to understanding of antidepressant drug action include a focus on early changes in emotional and social processing and the role of neural plasticity. In this Review, we discuss the ways in which these two different theories reflect different or complementary approaches, and how they might be integrated to offer novel solutions for people with depression. We consider the predictions made by these mechanistic approaches for the stratification and development of new therapeutics for depression, and the next steps that need to be made to facilitate this translation of science to the clinic.