Forensic characteristics and phylogenetic analysis of two Han populations from the southern coastal regions of China using 27 Y-STR loci
Forensic characteristics and phylogenetic analysis of two Han populations from the southern coastal regions of China using 27 Y-STR loci
复制标题
利用 27 个 Y-STR 位点对中国南部沿海地区两个汉族人群进行法医特征和系统发育分析。
DOI：
10.1016/j.fsigen.2017.10.009
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发表时间：
2017-11-01
影响因子：
3.1
通讯作者：
Hou, Yiping
中科院分区：
文献类型：
--
作者：
Wang, Mengge;Wang, Zheng;Hou, Yiping
目前，Y-STR单倍型参考数据库（YHRD, https://yhrd.org, release 55）中最大的国家数据库是中国，中国拥有非常庞大的Y-STR单倍型图谱。海南是中国最小的省份，也是中国最南端的省份，目前还没有单倍型数据。本研究招募了280名居住在海南省的无亲缘关系汉族男性，并对27个Y-STR位点进行了基因分型。此外，来自中国最大的移民城市深圳的136名汉人也接受了调查。海南汉族个体获得279种不同的单倍型，总单倍型多样性（HD）和辨别能力（DC）分别为0.999974和0.9964。深圳个体共有136个独特的单倍型，相关的HD和DC值均为1.0。两个多拷贝位点（DYS385a/b和DYF387S1a/b）和快速突变的Y-STRs （RM Y-STRs, DYS449, DYS518, DYS570, DYS576, DYS627）在两个汉族人群中表现出较高的遗传多样性（GD）值（GD >.7）。此外，我们还分析了中国行政区划和民族区划的遗传关系，并将我们的数据与现有的非中国群体数据集结合起来探索遗传变异。
Currently, the largest national database within the Y-STR Haplotype Reference Database (YHRD, https://yhrd.org, release 55) is China, which has a very large Y-STR haplotype profiles. However, no haplotype data was available for Hainan province, the smallest and southernmost province of China. Herein, 280 unrelated male Chinese Han individuals residing in Hainan province were recruited and genotyped with 27 Y-STR loci. Moreover, 136 Han individuals from Shenzhen, the largest migrant city in China, also investigated. 279 distinct haplotypes were obtained in the Hainan Han individuals with the overall haplotype diversity (HD) and discrimination capacity (DC) were 0.999974 and 0.9964, respectively. 136 unique haplotypes were observed in the Shenzhen individuals, and thus both of the related HD and DC values were 1.0. The two multi-copy loci (DYS385a/b and DYF387S1a/b) and rapidly mutating Y-STRs (RM Y-STRs, DYS449, DYS518, DYS570, DYS576, DYS627) exhibited high genetic diversity (GD) values (GD > 0.7) in two Han populations. Furthermore, genetic relationships along Chinese administrative and ethnic divisions were analyzed, and we also combined our data with existing datasets of non-Chinese groups to explore the genetic variance. Genetic differentiations were observed between Northern and Southern Han nationality, and genetic differences existed between the two Han populations and some ethnic groups, most prominently for the Tibetans and Kazakhs, as well as non-Chinese groups, especially African groups.