Knock-in of the Oas1br allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype
Knock-in of the Oas1br allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype
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DOI：
10.1016/j.virol.2007.08.017
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发表时间：
2007-11-25
期刊：
影响因子：
3.7
通讯作者：
Brinton, Margo A.
中科院分区：
文献类型：
--
作者：
Scherbik, Svetlana V.;Kluetzman, Kerri;Brinton, Margo A.
Inheritance patterns in mice suggested that resistance to flavivirus-induced disease was conferred by a single autosomal dominant allele (Flv(r)). A positional cloning strategy followed by comparison of F/v interval gene sequences from congenic resistant C3H.PRI-F/v(r) and susceptible C3H/He mouse strains identified the 2'-5'-oligoadenylate synthetase lb (Oas] b) gene as Flv. However, since these mouse strains differ by a 31 cM region, the possible involvement of differences in other linked genes in the resistant phenotype could not be absolutely ruled out. Knock-in of the Oaslb resistance allele into a susceptible mouse strain produced mice with the flavivirus resistance phenotype, confirming that this phenotype is mediated by a single gene. (c) 2007 Elsevier Inc. All rights reserved.
