The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control.
The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control.
复制标题
DOI：
10.1038/s41416-023-02442-4
复制
发表时间：
2023-12
影响因子：
8.8
通讯作者：
Ng, Tony
中科院分区：
文献类型：
--
作者：
Deng, Jinhai;Pan, Teng;Liu, Zaoqu;McCarthy, Caitlin;Vicencio, Jose M.;Cao, Lulu;Alfano, Giovanna;Suwaidan, Ali Abdulnabi;Yin, Mingzhu;Beatson, Richard;Ng, Tony
硫氧还蛋白相互作用蛋白（TXNIP）通常被认为是细胞氧化的主要调节因子，调节硫氧还蛋白（Trx）的表达和功能。最近的研究发现，TXNIP具有更广泛的额外作用：从调节葡萄糖和脂质代谢到细胞周期阻滞和炎症。它的表达通过在肿瘤细胞和更广泛的肿瘤微环境（TME）中常见的应激物而增加，因此，TXNIP已在癌症中被广泛研究。在这篇综述中，我们评估了目前的文献有关的监管和功能的TXNIP，突出其新兴的作用，在TME内不同类型的细胞之间的信号调节。然后，我们评估当前和未来的翻译机会以及该领域的相关挑战。对TXNIP在癌症中的功能和机制的进一步理解可能会增强其作为治疗靶点的适用性。
Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work has identified that TXNIP has a far wider range of additional roles: from regulating glucose and lipid metabolism, to cell cycle arrest and inflammation. Its expression is increased by stressors commonly found in neoplastic cells and the wider tumor microenvironment (TME), and, as such, TXNIP has been extensively studied in cancers. In this review, we evaluate the current literature regarding the regulation and the function of TXNIP, highlighting its emerging role in modulating signaling between different cell types within the TME. We then assess current and future translational opportunities and the associated challenges in this area. An improved understanding of the functions and mechanisms of TXNIP in cancers may enhance its suitability as a therapeutic target.
登录
查看更多内容
影响因子：
32.4
作者：
Bronner DN;Abuaita BH;Chen X;Fitzgerald KA;Nuñez G;He Y;Yin XM;O'Riordan MX
通讯作者：
O'Riordan MX
影响因子：
9.7
作者：
Cheng, Zhuoan;Lu, Chunlai;Qin, Wenxin
通讯作者：
Qin, Wenxin
影响因子：
12.8
作者：
Cho, Min Ji;Yoon, Sung-Jin;Min, Jeong-Ki
通讯作者：
Min, Jeong-Ki
CircRNA cRAPGEF5 通过 miR-27a-3p/TXNIP 通路抑制肾细胞癌的生长和转移。
影响因子：
9.7
作者：
Chen, Qiong;Liu, Tao;Wang, Linhui
通讯作者：
Wang, Linhui
影响因子：
5
作者：
Nakayama Y;Mukai N;Wang BF;Yang K;Patwari P;Kitsis RN;Yoshioka J
通讯作者：
Yoshioka J