Neurophysiological and psychological picture of solvent poisoning.
Neurophysiological and psychological picture of solvent poisoning.
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溶剂中毒的神经生理学和心理图。
DOI：
10.1002/ajim.4700010106
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发表时间：
1980
影响因子：
3.5
通讯作者：
T. Martelin
中科院分区：
文献类型：
--
作者：
A. Seppäläinen;K. Lindström;T. Martelin
对107名长期（男性平均9.6年，女性平均7.6年）职业暴露后诊断为溶剂中毒的患者（48名男性和59名女性）进行神经生理学和心理学测试。所有病例均采用脑电图（EEG）和广泛的心理测试组合，并对77名受试者进行神经电图测量。65%的患者表现出异常的脑电图，54%的患者出现了非药物诱导的过度β活动。77例患者中48例至少有一个神经传导速度（CV）异常减慢。男性的韦氏成人智力量表（WAIS）分测验数字广度（DSp）和数字符号（DSy）得分以及女性的相似性（Sim）、数字符号（DSy）、图片完成（PC）和区组设计（BD）得分均显著低于芬兰标准化样本。长时间接触与两性在圣安娜敏捷测试中的表现不佳有关，与男性的视觉记忆力差有关，与女性的视觉建设性智力任务差有关。EEG的背景频率与WAIS的DSp测验有相关性，与BD、对称性绘画测验、圣安娜敏捷测验、Mira测验也有一定的相关性。局灶性慢波异常与精神运动米拉测试中不准确的手部运动有关。神经生理学和心理学测试似乎部分反映了神经学效应的不同方面，它们的结合使用有助于评估溶剂暴露的危害。
Neurophysiological and psychological tests were administered to 107 patients--48 men and 59 women--with a diagnosis of solvent poisoning after longstanding (mean 9.6 years for males and mean 7.6 years for females) occupational exposure. Electroencephalography (EEG) and a wide psychological test battery were applied in all cases, and electroneurographic measurements were performed in 77 subjects. Sixty-five percent of the patients showed an abnormal EEG, and excessive beta activity, not induced by drugs, was found in 54% of patients. At least one abnormally slow nerve conduction velocity (CV) was found in 48 out of 77 patients. The scores of Wechsler Adult Intelligence Scale (WAIS) subtests Digit Span (DSp) and Digit Symbol (DSy) among the men and scores of Similarities (Sim), Digit Symbol (DSy), Picture Completion (PC), and Block Design (BD) among the women were statistically significantly lower than in the Finnish standardization sample. Long duration of exposure was related to poor performance in the Santa Ana Dexterity test in both sexes, to poor visual memory among the men and to poor visuoconstructive intellectual tasks among the women. The background frequency in the EEG showed a correlation to the DSp test of WAIS and some relationship emerged also between the former and the BD, the Symmetry Drawing test, the Santa Ana Dexterity test, and the Mira test. Focal slow wave abnormalities were related to inaccurate hand movements in the psychomotor Mira test. Neurophysiological and psychological tests seem to reflect partly different aspects of neurologic effects and their combined use helps in the evaluation of hazards of solvent exposure.