Streptozotocin-induced diabetes causes upregulation of serotonin (5-HT)2A/C receptors in lumbosacral cord motoneurons and down regulation of serotonergic paraneurons in the urethra
Streptozotocin-induced diabetes causes upregulation of serotonin (5-HT)2A/C receptors in lumbosacral cord motoneurons and down regulation of serotonergic paraneurons in the urethra
复制标题
链脲佐菌素诱导的糖尿病导致腰骶索运动神经元中血清素 (5-HT)2A/C 受体的上调和尿道中血清素能旁神经元的下调
DOI：
10.1016/j.brainres.2019.03.009
复制
发表时间：
2019-07-15
期刊：
影响因子：
2.9
通讯作者：
Andersson, Karl-Erik
中科院分区：
文献类型：
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作者：
Cao Nailong;Huang Jianwen;Andersson, Karl-Erik
下尿路功能障碍是糖尿病最常见的并发症。5-HT2a受体参与了乌拉坦麻醉DM大鼠的脊髓排尿控制。给予5-HT2A/2C受体激动剂2，5-甲氧基-4-碘苯丙胺(DOI)，刺激高频振荡(HFO)，改善排尿。然而，这些效应所涉及的机制还不完全清楚。结果表明，DM组脊髓运动神经元5-HT2A和(-2C)受体表达上调，尿路5-羟色胺能副动脉瘤数量减少。糖尿病患者的尿路副动脉瘤下调的重要性仍有待阐明，但可能与该病引起的尿路感觉减弱有关。我们认为，5-羟色胺受体激动剂改善排尿功能的靶点可能同时存在于LUT和腰椎脊髓。
Lower urinary tract (LUT) dysfunction is the most common complication of diabetes mellitus (DM). An involvement of the 5-HT2A receptor in spinal micturition control has been demonstrated in urethane anaesthetized DM rats in which i.v. administration of the 5-HT2A/2C receptor agonist 2,5-methoxy-4-iodoamphetamine (DOI), stimulated high frequency oscillations (HFOs) and improved micturition. However, the mechanisms involved in these effects are not completely understood. The present work showed that 5-HT2A and (-2C) receptors were upregulated in lumbosacral cord motoneurons, and the number of serotonergic paraneurons were downregulated in the urethra in DM group. The importance of the downregulation of urethral paraneurons in DM remains to be elucidated but may be related to the reduced urethral sensation caused by the disease. We suggest that targets of 5-HT receptor agonists for improvement of voiding function may be found both in the LUT and lumbosacral spinal cord.