Additive- and Metal-Free, Predictably 1,2- and 1,3-Regioselective, Photoinduced Dual C-H/C-X Borylation of Haloarenes.
Additive- and Metal-Free, Predictably 1,2- and 1,3-Regioselective, Photoinduced Dual C-H/C-X Borylation of Haloarenes.
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DOI：
10.1021/jacs.6b05436
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发表时间：
2016-07-13
影响因子：
15
通讯作者：
Larionov OV
中科院分区：
文献类型：
--
作者：
Mfuh AM;Nguyen VT;Chhetri B;Burch JE;Doyle JD;Nesterov VN;Arman HD;Larionov OV
本文报道了一种简单的、无添加剂和无金属的、光诱导的氯代芳烃、溴代芳烃和碘代芳烃的C-H/C-X双硼化反应。该反应在间歇和连续流动条件下以克级产生1，2-和1，3-二硼基芳烃。C-H/C-X双硼化反应的区域选择性取决于溶剂和母体卤代芳烃中的取代基。
We report herein a simple, additive- and metal-free, photoinduced, dual C–H/C–X-borylation of chloro-, bromo-, and iodoarenes. The reaction produces 1,2- and 1,3-diborylarenes on gram scales under batch and continuous flow conditions. The regioselectivity of the dual C–H/C–X-borylation is determined by the solvent and the substituents in the parent haloarenes.