Noninvasive measurement of cardiac output in healthy preterm and term newborn infants.
Noninvasive measurement of cardiac output in healthy preterm and term newborn infants.
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DOI：
10.1055/s-2007-999991
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发表时间：
1984-01-01
影响因子：
2
通讯作者：
Berman, W Jr
中科院分区：
文献类型：
--
作者：
Alverson, D C;Eldridge, M W;Berman, W Jr
虽然新生儿心输出量的数值以前有过报道，但所采用的方法是有创的。为了评估心输出量是否可以在新生儿中无创测定，我们使用便携式5MHz范围门控脉冲多普勒速度计测量了正常新生儿的平均升主动脉血流速度（VAo）。通过胸骨上入路测量了8个早产儿（平均出生体重1718克；平均估计孕龄33.3周）和14个足月（平均出生体重3127克；平均EGA 39.8周）1周龄以下的健康婴儿。超声测定内升主动脉收缩期内径，计算主动脉截面积：AAo = pi d2/4。升主动脉血流量（QAo）计算为QAo (ml/min) = VAo (cm/sec) X AAo (cm2) X 60 （sec/min）。排除动脉导管未闭（PDA）和可检测到的心内缺陷，取QAo等于心输出量。流量测定与体重归一化。8例早产儿平均心输出量为221 +/- 56 (+/- SD) ml/min/kg。14名足月婴儿的平均心输出量相似，为236 +/- 47 ml/min/kg。所有22名婴儿的平均心输出量为230±50。本研究建立了在健康婴儿出生后第一周，通过多普勒技术无创测定心输出量的正常值。这些数值与先前报道的全身血流量相似，这些血流量是通过心导管和热稀释方法在健康新生儿中测定的。
Although values for cardiac output in the newborn infant have been reported previously, the methods utilized have been invasive. To assess if cardiac output could be determined noninvasively in the neonate, we measured mean ascending aortic blood flow velocity (VAo) in well newborns using a portable 5MHz, range gated, pulsed Doppler velocity meter. Measurements were made from a suprasternal approach in 8 preterm (mean birth weight 1718 gm; mean estimated gestation age 33.3 weeks) and 14 term (mean birthweight 3127 gm; mean EGA 39.8 weeks) healthy infants under one week of age. The internal ascending aortic systolic diameter was determined echographically and aortic cross sectional area was calculated: AAo = pi d2/4. Ascending aortic blood flow (QAo) was then computed as QAo (ml/min) = VAo (cm/sec) X AAo (cm2) X 60 (sec/min). With the exclusion of patent ductus arteriosus (PDA) and detectable intracardiac defects, QAo was taken to equal cardiac output. Flow determinations were normalized to body weight. The 8 preterm infants had a mean cardiac output of 221 +/- 56 (+/- SD) ml/min/kg. The 14 term infants had a similar mean cardiac output of 236 +/- 47 ml/min/kg. The mean cardiac output of all 22 infants was 230 +/- 50. This study establishes normal values for cardiac output determined noninvasively by the Doppler technique, in the first week of life in healthy infants. These values are similar to previously reported systemic blood flows, which were determined by cardiac catheterization and thermodilution methods in healthy newborn infants.