Adaptation Improves Neural Coding Efficiency Despite Increasing Correlations in Variability
Adaptation Improves Neural Coding Efficiency Despite Increasing Correlations in Variability
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DOI：
10.1523/jneurosci.3449-12.2013
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发表时间：
2013-01-30
影响因子：
5.3
通讯作者：
Arabzadeh, Ehsan
中科院分区：
文献类型：
--
作者：
Adibi, Mehdi;McDonald, James S.;Arabzadeh, Ehsan
皮质细胞暴露于持续的感觉刺激导致神经元反应功能的变化。这种现象被称为适应，是感觉形态的共同特征。在这里，我们量化了适应对大鼠须桶系统中皮质神经元整体活动的功能影响。使用多柄电极阵列以允许同时采样神经元活动。我们的特点是神经元的反应，正弦晶须振动的不同幅度的三个国家的适应。衔接子在神经元反应功能中产生了系统性的平移。一致，互信息显示，峰值歧视的表现是不对齐的适配器，但测试振幅3-9 μ m高。刺激呈现降低了单个神经元试验间反应变异性（由Fano因子捕获）和群体反应变异性（噪声相关性）中的相关性。我们发现，这两种类型的变异性成反比的平均放电率，无论适应状态。适应转移神经元的操作制度，以更高的Fano因子和噪声相关性较低的利率。噪声相关性是正的并且在信号的方向上，并且因此不利于编码效率。有趣的是，在所有群体规模中，适应的净效应是增加总信息，尽管增加了神经元之间的噪声相关性。
Exposure of cortical cells to sustained sensory stimuli results in changes in the neuronal response function. This phenomenon, known as adaptation, is a common feature across sensory modalities. Here, we quantified the functional effect of adaptation on the ensemble activity of cortical neurons in the rat whisker-barrel system. A multishank array of electrodes was used to allow simultaneous sampling of neuronal activity. We characterized the response of neurons to sinusoidal whisker vibrations of varying amplitude in three states of adaptation. The adaptors produced a systematic rightward shift in the neuronal response function. Consistently, mutual information revealed that peak discrimination performance was not aligned to the adaptor but to test amplitudes 3-9 mu m higher. Stimulus presentation reduced single neuron trial-to-trial response variability (captured by Fano factor) and correlations in the population response variability (noise correlation). We found that these two types of variability were inversely proportional to the average firing rate regardless of the adaptation state. Adaptation transferred the neuronal operating regime to lower rates with higher Fano factor and noise correlations. Noise correlations were positive and in the direction of signal, and thus detrimental to coding efficiency. Interestingly, across all population sizes, the net effect of adaptation was to increase the total information despite increasing the noise correlation between neurons.