PERMSELECTIVITY OF GLOMERULAR CAPILLARY WALL - FACILITATED FILTRATION OF CIRCULATING POLYCATIONS
PERMSELECTIVITY OF GLOMERULAR CAPILLARY WALL - FACILITATED FILTRATION OF CIRCULATING POLYCATIONS
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DOI：
10.1172/jci108927
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发表时间：
1978-01-01
影响因子：
15.9
通讯作者：
BRENNER, BM
中科院分区：
文献类型：
--
作者：
BOHRER, MP;BAYLIS, C;BRENNER, BM
为了研究固定负电荷对肾小球毛细血管壁的静电效应，将多分散[3 H]DEAE葡聚糖（葡聚糖的聚阳离子形式）注入10只Munich-Wistar大鼠。半径范围为18-44埃的DEAE清除率分数。在这些大鼠中确定，连同直接测量的力量和流量的肾小球滤过率的水。这些结果与接受3 H-中性葡聚糖（D）和聚阴离子硫酸葡聚糖（DS）的Munich-Wistar大鼠的数据进行了比较。给予DEAE的大鼠肾小球水滤过率的决定因素的测量值与给予D或DS的大鼠基本相同。DEAE既不分泌也不重吸收。相对于D和DS，聚阳离子DEAE的部分清除率增加，相对于D的增加对于24-44埃的有效分子半径范围是显著的。
To examine the electrostatic effects of fixed negative charges on the glomerular capillary wall, polydisperse [3H]DEAE dextran, a polycationic form of dextran, was infused into 10 Munich-Wistar rats. Fractional clearances of DEAE ranging in radius from 18-44 .ANG. were determined in these rats, together with direct measurements of the forces and flows governing the glomerular filtration rate of water. These results were compared with data on Munich-Wistar rats receiving 3H-neutral dextran (D) and polyanionic dextran sulfate (DS). Measured values for the determinants of the glomerular filtration rate of water in rats given DEAE were essentially identical to those in rats given either D or DS. DEAE was neither secreted nor reabsorbed. Fractional clearances of polycationic DEAE were increased relative to both D and DS, the increase relative to D being significant for effective molecular radii ranging from 24-44 .ANG.