Negative childhood experiences alter a prefrontal-insular-motor cortical network in healthy adults: A preliminary multimodal rsfMRI-fMRI-MRS-dMRI study.
Negative childhood experiences alter a prefrontal-insular-motor cortical network in healthy adults: A preliminary multimodal rsfMRI-fMRI-MRS-dMRI study.
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DOI：
10.1002/hbm.22941
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发表时间：
2015-11
影响因子：
4.8
通讯作者：
Northoff G
中科院分区：
文献类型：
--
作者：
Duncan NW;Hayes DJ;Wiebking C;Tiret B;Pietruska K;Chen DQ;Rainville P;Marjańska M;Ayad O;Doyon J;Hodaie M;Northoff G
对人类和动物的研究表明，负面的童年经历（NCE）会对大脑的结构和功能产生长期影响。在灰色和白色物质中，在大脑的休息状态下，在神经系统中，以及在对厌恶刺激的神经和行为反应中，都注意到了变化。这些影响可能与精神疾病有关，如抑郁症和焦虑症，这些疾病受到过度暴露于早期生活压力的影响。本研究的目的是调查NCE对这些系统的影响。在健康受试者中，将静息状态功能MRI（rsfMRI）、厌恶任务fMRI、谷氨酸磁共振波谱（MRS）和弥散磁共振成像（dMRI）与儿童创伤问卷（CTQ）相结合，以检查NCE对大脑的影响。低CTQ分数，NCE的测量，与较高的静息态谷氨酸水平和较高的静息态熵在内侧前额叶皮层（mPFC）。CTQ分数，mPFC谷氨酸和熵，与神经BOLD反应的预期厌恶刺激的区域在整个厌恶相关的网络，在运动皮层和左额叶皮层的所有措施之间的强相关性。结构连接强度，测量使用平均分数各向异性，mPFC和左前额叶皮层之间的相关运动皮层的厌恶相关的信号变化。这些发现强调了NCE对多个相互关联的大脑系统的影响。特别是，他们强调了前额叶-岛叶-运动皮层网络在处理和反应厌恶刺激及其潜在的适应性NCE的作用。
Research in humans and animals has shown that negative childhood experiences (NCE) can have long-term effects on the structure and function of the brain. Alterations have been noted in grey and white matter, in the brain’s resting state, on the glutamatergic system, and on neural and behavioural responses to aversive stimuli. These effects can be linked to psychiatric disorder such as depression and anxiety disorders that are influenced by excessive exposure to early life stressors. The aim of the current study was to investigate the effect of NCEs on these systems. Resting state functional MRI (rsfMRI), aversion task fMRI, glutamate magnetic resonance spectroscopy (MRS), and diffusion magnetic resonance imaging (dMRI) were combined with the Childhood Trauma Questionnaire (CTQ) in healthy subjects to examine the impact of NCEs on the brain. Low CTQ scores, a measure of NCEs, were related to higher resting state glutamate levels and higher resting state entropy in the medial prefrontal cortex (mPFC). CTQ scores, mPFC glutamate and entropy, correlated with neural BOLD responses to the anticipation of aversive stimuli in regions throughout the aversion-related network, with strong correlations between all measures in the motor cortex and left insula. Structural connectivity strength, measured using mean fractional anisotropy, between the mPFC and left insula correlated to aversion-related signal changes in the motor cortex. These findings highlight the impact of NCEs on multiple inter-related brain systems. In particular, they highlight the role of a prefrontal-insular-motor cortical network in the processing and responsivity to aversive stimuli and its potential adaptability by NCEs.