Hemodynamic effects of endothelin-1 in the newborn piglet: influence on pulmonary and systemic vascular resistance.
Hemodynamic effects of endothelin-1 in the newborn piglet: influence on pulmonary and systemic vascular resistance.
复制标题
内皮素 1 对新生仔猪的血流动力学影响：对肺和全身血管阻力的影响。
DOI：
10.1097/00005344-199100177-00092
复制
发表时间：
1991
影响因子：
3
通讯作者：
Henry,W
中科院分区：
文献类型：
--
作者：
Krzeski,R;Long,W;Katayama,H;Henry,W
本研究旨在探讨内皮素-1（ET-1）对新生仔猪肺循环和体循环的影响。用氯醛糖-氨基甲酸乙酯麻醉12头仔猪（平均年龄6.8天，范围1-12天），并在FiO 2 = 1.0下通气。测量心输出量（CO）、肺动脉压（PAP）、主动脉压（AoP）、左心房压（AoP）和右心房压（RAP）。6头仔猪经肺动脉注入生理盐水（对照组）和ET-1（500 ng/kg），同时每隔20 s测定PAP、AoP、MAP、RAP、CO和心率（HR），计算肺血管阻力（PVR）和体循环阻力（SVR）。PA中给予ET-1导致（a）平均PAP（[DELTA] max为-4 +/-2 mm Hg）短暂降低。p< 0.001）;（B）PVR的双相反应（初始下降，随后显著增加）（[DELTA] max为-760 +/-460 dyn cm/s，p< 0.01）。和[DELTA] max为+ 1.490+/-1，360 dyn cm/s5 p< 0.05）和AoP（[DELTA] max为-12 +/-7 mmHg，p< 0.005，[DELTA] max为+ 11+/-6 mmHg，p< 0.005）：（c）SVR增加（[DELTA]最大值为+5，930 +/-2，330达因cm/s5 p< 0.05）;和（d）CO的初始增加（[DELTA] max为+0.06 +/-0.03 L/min，p< 0.05），随后降低（[DELTA] max为-0.09 +/-0.05 L/min，p< 0.05）。这些反应尚未在成年物种中观察到，可能表明肺循环对ET-1给药的反应存在发育差异。
The aim of this study was to investigate the influence of endothelin-1 (ET-1) on the pulmonary and systemic circulations in newborn piglets. Twelve piglets (mean age of 6.8 days, range of 1-12 days) were anesthetized with chloralose-urethane and ventilated at FiO2= 1.0. Animals were instrumented to measure cardiac output (CO), pulmonary artery pressure (PAP), aortic pressure (AoP), left atrial pressure (LAP), and right atrial pressure (RAP). Six piglets received a control saline injection into the pulmonary artery (PA), and six piglets received one injection of ET-1 (500 ng/kg) into the PA while PAP, AoP, LAP, RAP, CO, and heart rate (HR) were measured simultaneously at 20-s intervals with pulmonary vascular resistance (PVR) and systemic vascular resistance (SVR) calculated by computer. Administration of ET-1 into the PA led to (a) a transient decrease in mean PAP ([DELTA] max of-4+/-2 mm Hg. p< 0.001);(b) a biphasic response (an initial decline followed by a substantial increase) in PVR ([DELTA] max of-760+/-460 dyn cm/s5 p< 0.01. and [DELTA] max of+ 1.490+/-1,360 dyn cm/s5 p< 0.05) and in AoP ([DELTA] max of-12+/-7 mm Hg, p< 0.005, and [DELTA] max of+ 11+/-6 mm Hg, p< 0.005):(c) an increase in SVR ([DELTA] max of+ 5,930+/-2,330 dyn cm/s5 p< 0.05); and (d) an initial increase in CO ([DELTA] max of+ 0.06+/-0.03 L/min, p< 0.05) followed by a decrease ([DELTA] max of-0.09+/-0.05 L/min, p< 0.05). These responses have not been observed in adult species and may indicate a developmental difference in the response of the pulmonary circulation to ET-1 administration.