Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards.
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards.
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DOI：
10.1038/ncomms12150
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发表时间：
2016-07-06
影响因子：
16.6
通讯作者：
Gabrilovich DI
中科院分区：
文献类型：
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作者：
Bronte V;Brandau S;Chen SH;Colombo MP;Frey AB;Greten TF;Mandruzzato S;Murray PJ;Ochoa A;Ostrand-Rosenberg S;Rodriguez PC;Sica A;Umansky V;Vonderheide RH;Gabrilovich DI
骨髓源性抑制细胞（MDSC）是在癌症和其他慢性炎症条件下扩增的异质群体。在这里，作者确定了挑战，并提出了一套小鼠和人类MDSC的最低报告指南。骨髓源性抑制细胞（MDSC）已成为癌症和其他病理条件下免疫反应的主要调节因子。近年来，大量证据支持MDSC通过免疫介导的机制和与免疫抑制不直接相关的机制对肿瘤进展的关键贡献。MDSC是深入研究的主题，仅2015年就发表了超过500篇论文。然而，这些细胞的表型、形态和功能的异质性在研究和分析它们在炎症反应中的作用时产生了混乱。本通信的目的是在新兴的MDSC研究领域提出表征标准。
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population expanded in cancer and other chronic inflammatory conditions. Here the authors identify the challenges and propose a set of minimal reporting guidelines for mouse and human MDSC. Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.