Dynamics of estrogen induction of glandular kallikrein in the rat anterior pituitary.
Dynamics of estrogen induction of glandular kallikrein in the rat anterior pituitary.
复制标题
雌激素诱导大鼠垂体前叶腺激肽释放酶的动态。
DOI：
10.1016/0304-4165(87)90211-x
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Powers,CA
中科院分区：
文献类型：
--
作者：
Hatala,MA;Powers,CA
腺激肽释放酶最近被确定为大鼠垂体前叶的雌激素诱导蛋白。本研究探讨了去卵巢大鼠垂体前叶腺激肽释放酶的雌激素诱导动力学。为了比较，还检查了子宫干重的雌激素诱导。17 β-雌二醇（0.1 - 100 μ g/天）使垂体前叶腺性激肽释放酶呈剂量依赖性增加，最高剂量增加60倍。时程研究表明，在这些雌激素对腺激肽释放酶的影响变得明显之前，需要2 - 3天的滞后期，并且在治疗的7 - 10天之间水平仍在上升。腺激肽释放酶的雌激素诱导的动力学类似于雌激素诱导子宫干重的雌激素敏感性和雌激素诱导的增加之前的滞后期的存在。然而，子宫干重对雌激素的反应比垂体前叶腺激肽释放酶更快，并在雌激素治疗5天后达到平台。
Glandular kallikrein has recently been identified as an estrogen-induced protein of the rat anterior pituitary. This study examined the dynamics of the estrogen induction of anterior pituitary glandular kallikrein in the ovariectomized rat. The estrogen induction of uterine dry weight was also examined for purposed of comparison. 17β-Estradiol (0.1–100 μg/day) produced dose-dependent increases in anterior pituitary glandular kallikrein, with the highest dose producing a 60-fold increase. Time-course studies demonstrated that a lag phase of 2–3 days was required before these estrogen effects on glandular kallikrein became evident, and levels were still rising between 7 and 10 days of treatment. The dynamics of the estrogen induction of glandular kallikrein resembled the estrogen induction of uterine dry weight with regard to estrogen sensitivity and the presence of a lag phase before estrogen-induced increases. However, uterine dry weight responde more rapidly to estrogen than did anterior pituitary glandular kallikrein, and reached a plateau after 5 days of estrogen treatment.