A new phytotoxic nonenolide from Phoma herbarum
A new phytotoxic nonenolide from Phoma herbarum
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DOI：
10.1021/np020501t
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发表时间：
2003-04-01
影响因子：
5.1
通讯作者：
Mata, R
中科院分区：
文献类型：
--
作者：
Rivero-Cruz, JF;Macías, M;Mata, R
发酵液和菌丝体的再研究。的真菌Phoma herbarum的分离，导致一种新的植物毒性壬烯，即（7 R，9 R）-7-羟基-9-丙基-5-壬烯-9-酮，其被命名为平凡的名称herbarumin III（3）。还得到了已知化合物herbarumins 1（1）和11（2）。通过光谱学方法和分子模拟方法确定了化合物3的结构。化合物1-3与牛脑钙调素相互作用，并抑制钙调素依赖性酶cAMP磷酸二酯酶的活化。
Reinvestigation of the fermentation broth and mycelium. of the fungus Phoma herbarum led to the isolation of a new phytotoxic nonenolide, namely, (7R,9R)-7-hydroxy-9-propyl-5-nonen-9-olide, which was designated with the trivial name herbarumin III (3). The known compounds herbarumins 1 (1) and 11 (2) were also obtained. The structure of 3 was elucidated by spectroscopic methods and molecular modeling. Compounds 1-3 interacted with bovine-brain calmodulin and inhibited the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase.