The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea.
The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea.
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健脾解毒中药对禁食和腹泻预处理的原位移植性肝癌大鼠模型中 OATP1B2 和 ABCC2 的调节作用
DOI：
10.1155/2015/752850
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发表时间：
2015
影响因子：
--
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Sun B;Chen Y;Xiang T;Zhang L;Chen Z;Zhang S;Zhou H;Chen S
中医健脾解毒汤（JPJD）在临床上可改善肝癌患者的一般状况，尤其是食欲减退和腹泻症状。在本研究中，我们的结果显示，伴有饮食限制和腹泻的肝癌（FRD - LC）大鼠的存活率低于肝癌（LC）大鼠，且FRD - LC大鼠的肿瘤体积大于LC大鼠。还表明与FRD - LC诱导的大鼠相比，高剂量的JPJD显著提高了存活率、体重和器官重量。此外，JPJD给药上调了肝脏组织中ABCC2的mRNA和蛋白质水平，并下调了OATP1B2的mRNA和蛋白质水平。然而，在癌组织中观察到了相反的结果。总之，该研究表明，中药JPJD可通过调节肝脏组织和癌组织中ABCC2和OATP1B2的表达，对经过饮食限制和腹泻预处理的肝癌大鼠产生有益作用。
Traditional Chinese Medicine Jianpijiedu decoction (JPJD) could improve the general status of liver cancer patients in clinics, especially the symptoms of decreased food intake and diarrhea. In this study, our results showed that the survival rate of the liver cancer with food restriction and diarrhea (FRD-LC) rats was lower than the liver cancer (LC) rats, and the tumor volume of the FRD-LC rats was higher than the LC rats. It was also shown that the high dose of JPJD significantly improved the survival rate, weight, and organ weight when compared with FRD-LC-induced rats. Moreover, JPJD administration upregulated the mRNA and protein levels of ABCC2 and downregulated the mRNA and protein levels of OATP1B2 in liver tissues. However, opposite results were observed in the cancer tissues. In conclusion, the study indicated that the Chinese Medicine JPJD could contribute to the rats with liver cancer which were pretreated with food restriction and diarrhea by regulating the expression of ABCC2 and OATP1B2 in liver tissues and cancer tissues.