Association between components of the insulin-like growth factor system and endometrial cancer risk
Association between components of the insulin-like growth factor system and endometrial cancer risk
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DOI：
10.1159/000080286
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发表时间：
2004-01-01
期刊：
影响因子：
3.5
通讯作者：
La Vecchia, C
中科院分区：
文献类型：
--
作者：
Augustin, LSA;Dal Maso, L;La Vecchia, C
目的：胰岛素样生长因子（IGF）系统与细胞增殖、肥胖、糖尿病、高胰岛素血症和子宫内膜癌风险有关。我们使用了在意大利进行的一项病例对照研究的数据，以提供关于IGF系统与子宫内膜癌之间关系的额外信息。方法：1999年至2002年在意大利进行了一项病例对照研究，其中包括73例组织学证实的子宫内膜癌妇女和108例因急性非肿瘤性疾病在同一医院网络就诊的对照组。所有受试者均采用有效问卷进行访谈。结果：比较各种IGF成分最高和最低的比值比，子宫内膜癌的比值比如下：游离IGF- i为0.5[95%可信区间（CI） 0.2-1.2]，总IGF- i为1.1(95%可信区间（CI） 0.5-2.6)，总IGF- ii为1.2 (95% CI 0.6-2.6)， IGF结合蛋白(IGFBP)-1为2.4 (95% CI 1.0-5.9)， IGFBP-3为0.8 （95% CI 0.4-2.0）。进一步考虑模型中所有IGF成分并没有改变结果。与IGFBP-1的直接关系更强，且仅限于体重较重和年龄较大的女性。结论：目前的研究结果表明，IGF系统对子宫内膜癌风险的影响有限。在老年妇女和体重指数较高的妇女中，升高的IGFBP-1水平似乎与子宫内膜癌的风险有关。版权所有(C) 2004 S. Karger AG，巴塞尔。
Objective: The insulin-like growth factor (IGF) system has been related to cell proliferation, obesity, diabetes, hyperinsulinemia and endometrial cancer risk. We used data from a case-control study conducted in Italy to provide additional information on the relation between the IGF system and endometrial cancer. Methods: A case-control study was conducted between 1999 and 2002 in Italy, including a total of 73 women with incident, histologically confirmed endometrial cancer and 108 controls admitted to the same hospital network for acute, nonneoplastic diseases. All subjects were interviewed using a validated questionnaire. Results: The odds ratios for endometrial cancer comparing the highest versus the lowest tertile of various IGF components were as follows: 0.5 [95% confidence interval (CI) 0.2-1.2] for free IGF-I, 1.1 (95% CI 0.5-2.6) for total IGF-I, 1.2 ( 95% CI 0.6-2.6) for total IGF-II, 2.4 (95% CI 1.0-5.9) for IGF binding protein (IGFBP)-1 and 0.8 (95% CI 0.4-2.0) for IGFBP-3. Further allowance for all IGF components in the model did not modify the results. The direct relation with IGFBP-1 was stronger and limited to heavier and older women. Conclusions: The present findings suggest a limited effect of the IGF system on endometrial cancer risk. Increasing IGFBP-1 levels seem to be associated with endometrial cancer risk in older women and in women with a higher body mass index. Copyright (C) 2004 S. Karger AG, Basel.