Readiness for HIV vaccine trials: Changes in willingness and knowledge among high-risk populations in the HIV network for prevention trials
Readiness for HIV vaccine trials: Changes in willingness and knowledge among high-risk populations in the HIV network for prevention trials
复制标题
DOI：
10.1097/00126334-200008150-00010
复制
发表时间：
2000-08-15
期刊：
影响因子：
--
通讯作者：
Heagerty, P
中科院分区：
文献类型：
--
作者：
Koblin, BA;Holte, S;Heagerty, P
纵向数据进行了分析，以确定在HIV-1感染的高危人群中参与HIV疫苗有效性试验的意愿和疫苗试验概念的知识的变化。男同性恋者（MSM），男性和女性注射毒品使用者，和非注射女性在异性恋的风险招募（n = 4892）。随访访视每6个月进行一次，最长18个月。与基线相比，随访访视时的意愿显著降低。所有研究人群的知识水平都有所提高。有问题的概念是疫苗对免疫系统的可能影响，以及在试验开始前缺乏对疫苗有效性的了解。对于安全性、盲法和保证未来参与试验的概念，男男性接触者的知识有显著增加，但其他人群几乎没有变化。知识的增加与变得不愿意，特别是在低知识水平的男男性行为者。至少有一半的高风险参与者始终愿意参加未来疫苗有效性试验，并且通过基础疫苗教育，知识水平有所提高。需要在社区和个人层面继续开展教育工作，以解决某些疫苗试验概念，并提高所有潜在研究人群的知识水平。
Longitudinal data were analyzed to determine changes in willingness to participate in HIV vaccine efficacy trials and knowledge of vaccine trial concepts among populations at high risk of HIV-I infection. Gay men (MSM), male and female injection drug users, and non-injecting women at heterosexual risk were recruited(n = 4892). Follow-up visits occurred every 6 months up to 18 months. Willingness was significantly lower at follow-up visits compared with at baseline. Knowledge levels increased for all study populations. Problematic concepts were possible effects of the vaccine on the immune system and lack of knowledge about efficacy of a vaccine before the start of a trial. For concepts concerning safety, blinding, and guarantees of future participation in trials, MSM men had significant increases in knowledge, but little to no change occurred for the other populations. An increase in knowledge was associated with becoming not willing, particularly among MSM with low knowledge levels. At least half of high-risk participants were consistently willing to participate in Future vaccine efficacy trials and with basic vaccine education, knowledge levels increased. Continued educational efforts at the community and individual level are needed to address certain vaccine trial concepts and to increase knowledge levels in all potential study populations.