Successful treatment of refractory chronic disseminated candidiasis after prolonged administration of caspofungin in a child with acute myeloid leukemia
Successful treatment of refractory chronic disseminated candidiasis after prolonged administration of caspofungin in a child with acute myeloid leukemia
复制标题
长期服用卡泊芬净成功治疗急性髓系白血病儿童难治性慢性播散性念珠菌病
作者：
U. Kontny;T. Walsh;J. Rossler;M. Uhl;C. Niemeyer
本报告记录了卡泊芬净在一名患有急性髓系白血病 (AML) 和慢性播散性念珠菌病 (CDC) 且对两性霉素 B 和氟康唑耐药的 13 岁女孩中的临床活性。卡泊芬净开始服用 50 mg/d，产生暂时反应。治疗 2 个月后，由于没有进一步的临床改善和放射学进展，卡泊芬净的剂量增加至 100 mg/d，产生了持续的临床反应。治疗总共进行了 12 个月，没有出现任何不良反应。这种方法成功地用卡泊芬净治疗了难治性 CDC。儿科血癌 2007 年；49：360–362。 © 2006 Wiley-Liss, Inc.
This report documents the clinical activity of caspofungin in a 13‐year‐old girl with acute myeloid leukemia (AML) and chronic disseminated candidiasis (CDC), refractory to amphotericin B and fluconazole. Caspofungin was started at 50 mg/d resulting in a temporary response. With no further clinical improvement and radiological progress after 2 months of therapy, the dose of caspofungin was increased to 100 mg/d, leading to a sustained clinical response. Therapy was given for a total of 12 months and had no attributable adverse effects. This approach resulted in successful treatment of refractory CDC with caspofungin. Pediatr Blood Cancer 2007;49:360–362. © 2006 Wiley‐Liss, Inc.
影响因子：
158.5
作者：
Walsh, TJ;Teppler, H;dePauw, BE
通讯作者：
dePauw, BE