Fasciola hepatica, TGF-ß and host mimicry: the enemy within.
Fasciola hepatica, TGF-ß and host mimicry: the enemy within.
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肝片形吸虫、TGF-β 和宿主拟态：内部的敌人。
DOI：
10.1016/j.mib.2018.09.002
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发表时间：
2018
影响因子：
5.4
通讯作者：
Musah-Eroje M
中科院分区：
文献类型：
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作者：
Musah-Eroje M
除了建立慢性感染之外，蠕虫寄生虫还会在其最终宿主内经历发育变化和迁移。对此至关重要的是逃避宿主免疫反应。典型的 Th2 反应可有效清除肠道内的寄生虫。相反，蠕虫也促进抗原特异性无反应和调节的发展。这通常会限制病理学，但允许寄生虫存活，介导这一点的寄生虫效应器是深入研究的主题。它们可能可用作未来的疫苗靶标或异种疗法。肝片形吸虫拥有一系列 TGF 样分子，其中一个成员 FhTLM 能够促进内在和外在作用。在这里，我们回顾 FhTLM 对宿主巨噬细胞的外在影响及其对保护性免疫的影响。这篇综述还根据最近对线虫 TGF-β 模拟物的描述以及内源性 TGF-β 的影响讨论了 FhTLM 的特异性。
Helminths parasites undergo developmental changes and migration within their definitive host, in addition to establishing chronic infection. Essential to this is the evasion of host immune responses; the canonical Th2 response is effective at removing parasites resident in the intestine. Conversely, helminths also promote the development of antigen-specific anergy and regulation. This often limits pathology but allows parasite survival, parasite effectors mediating this are the subject of intense study. They may be useful as future vaccine targets or xenogenic therapeutics. Fasciola hepatica possesses a family of TGF-like molecules of which one member, FhTLM, is capable of promoting intrinsic and extrinsic effects. Here we review the extrinsic effects of FhTLM on the host macrophage and its consequences for protective immunity. This review also discusses the specificities of FhTLM in light a very recent description of a nematode TGF-β mimic and the effects of endogenous TGF-β.