CYTOGENETICS AND INFERTILITY IN MAN .2. TESTICULAR HISTOLOGY AND MEIOSIS
CYTOGENETICS AND INFERTILITY IN MAN .2. TESTICULAR HISTOLOGY AND MEIOSIS
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DOI：
10.1111/j.1469-1809.1976.tb00176.x
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发表时间：
1976-01-01
影响因子：
1.9
通讯作者：
WATSON, GS
中科院分区：
文献类型：
--
作者：
CHANDLEY, AC;MACLEAN, N;WATSON, GS
在一组207低生育力的男性，选择睾丸活检，组织学研究成功地在194染色体正常和7染色体异常的个人。染色体核型正常的男性（52%）睾丸组织学正常，31%表现为精子发生的普遍抑制，8%表现为晚期缺陷。10%的人睾丸中只有支持细胞。在染色体异常的男性中观察到的睾丸状况的范围与在染色体正常的男性中发现的相似。对118个染色体正常个体进行的减数分裂研究得出平均交叉计数为48.9/细胞。在终变期/中期I（显示X和Y单价体）的高细胞数与达到中期II的低细胞数之间呈正相关。研究了3例易位杂合子的减数分裂，其中1例为47，XYY男性，1例为47，XY +mar个体，1例为环状Y染色体。
Within a group of 207 subfertile men, selected for testicular biopsy, histological investigations were made successfully in 194 chromosomally normal and 7 chromosomally abnormal individuals. Men (52%) with a normal karyotype showed normal testicular histology, 31% showed a general depression of spermatogenesis and 8% showed deficiency in the late stages. Ten percent had only Sertoli cells in the testis. The range of testicular conditions seen in the chromosomally abnormal men was similar to that found in the chromosomally normal. Meiotic studies carried out on 118 chromosomally normal individuals gave a mean chiasma count of 48.9/cell. There was a positive correlation between high numbers of cells at diakinesis/metaphase I showing X and Y univalents and low numbers of cells reaching metaphase II. Meiosis was studied in 3 translocation heterozygotes, one 47,XYY male, one 47,XY +mar individual and 1 patient with a ring Y chromosome.