FATTY LIVER IN RAT AFTER PROLONGED INTAKE OF ETHANOL WITH A NUTRITIONALLY ADEQUATE NEW LIQUID DIET
FATTY LIVER IN RAT AFTER PROLONGED INTAKE OF ETHANOL WITH A NUTRITIONALLY ADEQUATE NEW LIQUID DIET
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DOI：
10.1093/jn/91.3_suppl.331
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发表时间：
1967-01-01
影响因子：
4.2
通讯作者：
LIEBER, CS
中科院分区：
文献类型：
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作者：
DECARLI, LM;LIEBER, CS
为了确定长期摄入乙醇是否会产生脂肪肝，即使饮食中含有足够的蛋白质、矿物质和维生素，给大鼠喂食含有18%酪蛋白热量的流质饮食，并补充蛋氨酸（0.3毫克/千卡）和胱氨酸（0.5毫克/千卡），胆碱（0.25毫克/千卡），脂肪（总热量的35%），足够的矿物质和维生素，在对照饮食中，47%的热量为碳水化合物。每只对照大鼠的同窝出生仔用相同的饮食配对喂养，其中碳水化合物已被等热量地用酒精替代，达到总热量的36%。这些饮食保证了所有动物的持续生长和对照组的正常肝脏，而在用酒精喂养的大鼠中，脂肪肝发生了，这在形态学和化学分析上都很明显;与对照组相比，酒精喂养24天后，肝脏甘油三酯平均增加了6倍，胆固醇酯增加了5倍。这些研究表明，即使饮食中含有足够的蛋白质、维生素和矿物质，脂肪含量低于美国人的平均饮食，长期饮酒也会产生脂肪肝。
TO determine whether prolonged ethanol intake can produce a fatty liver, even when associated with a diet containing adequate amounts of protein, minerals and vitamins, rats were given liquid diets containing 18% of calories as casein, supplemented with methionine (0.3 mg/kcal) and cystine (0.5 mgAcal), choline (0.25 mg/kcal), fat (35% of total calories), adequate minerals and vitamins and, in the control diet, 47% of the calories as carbohydrates. A littermate of each control rat was pair-fed with the same diet in which carbohydrates had been isocalorically replaced with alcohol to the extent of 36% of the total calories. These diets assured continued growth in all animals and normal liver in the controls, whereas in the rats fed with alcohol, fatty liver developed, which was evident both morphologically and on chemical analysis; after 24 days of alcohol, hepatic triglycerides had increased on the average sixfold and cholesterol esters fivefold, compared with those of the controls. These studies demonstrate that prolonged alcohol intake can produce a fatty liver even when given with a diet with nutritionally adequate content of protein, vitamins and minerals, and an amount of fat less than that of the average American diet.