Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function
Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function
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DOI：
10.1016/s0012-1606(03)00103-9
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发表时间：
2003-05-15
影响因子：
2.7
通讯作者：
Andrew, DJ
中科院分区：
文献类型：
--
作者：
Bradley, PL;Myat, MM;Andrew, DJ
器官的最终整体形状及其在发育中的胚胎中的位置是由于其固有属性及其与周围组织的相互作用而产生的。在这里，我们关注定向细胞迁移在果蝇唾液腺形成和定位中的作用。我们证明唾液腺沿着内脏中胚层旋转和迁移，以变得相对于整个胚胎适当地定向。我们发现，唾液腺后向迁移需要定位内脏中胚层前体的基因的活动，如无情、粗静脉和锡人，但不需要分化的内脏中胚层。我们还展示了整合素在唾液腺迁移中的作用。虽然影响唾液腺运动和定向迁移的突变会导致唾液腺的最终定位出现缺陷，但大多数突变不会影响唾液腺导管的长度或直径。这些发现表明唾液管的大小可能是唾液腺细胞的一种固有特性。(C)2003年埃尔塞维尔科学公司(美国)。版权所有。
The final overall shape of an organ and its position within the developing embryo arise as a consequence of both its intrinsic properties and its interactions with surrounding tissues. Here, we focus on the role of directed cell migration in shaping and positioning the Drosophila salivary gland. We demonstrate that the salivary gland turns and migrates along the visceral mesoderm to become properly oriented with respect to the overall embryo. We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thick-veins, and tinman, but does not require a differentiated visceral mesoderm. We also demonstrate a role for integrin function in salivary gland migration. Although the mutations affecting salivary gland motility and directional migration cause defects in the final positioning of the salivary gland, most do not affect the length or diameter of the salivary gland tube. These findings suggest that salivary tube dimensions may be an intrinsic property of salivary gland cells. (C) 2003 Elsevier Science (USA). All rights reserved.