Manufacturing Processes of Implantable Microelectrode Array for In Vivo Neural Electrophysiological Recordings and Stimulation: A State-Of-the-Art Review.
Manufacturing Processes of Implantable Microelectrode Array for In Vivo Neural Electrophysiological Recordings and Stimulation: A State-Of-the-Art Review.
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用于体内神经电生理记录和刺激的植入式微电极阵列的制造工艺：最先进的综述。
DOI：
10.1115/1.4063179
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Chen,Lei
中科院分区：
文献类型：
--
作者：
Yi,Dongyang;Yao,Yao;Wang,Yi;Chen,Lei
神经元活动的电生理记录和刺激对于我们了解神经系统的功能和功能障碍是重要的。微电极阵列（MEA）植入物是一种很有前途的工具，可以在细胞外记录/刺激神经元的活动，作为电压波动，为神经科学研究和医疗提供高的时间和空间分辨率。自从多边环境协定的发明和制造工艺的发展以来，多边环境协定的设计配置和记录能力已经发生了巨大的变化，这是这种进步的关键驱动力。在过去的十年中，自2013年推出的白宫通过推进创新神经技术（BRAIN）进行脑研究倡议以来，先进的制造工艺使先进的MEA具有增加的通道数量和密度，进入更多的大脑区域，更可靠的慢性性能，以及最小的侵入性和组织反应。在这个国家的最先进的综述文件中，三个主要类型的电生理记录膜电极现在广泛使用，即，基于微丝，硅基，和灵活的膜电极进行了介绍和讨论。传统的设计和制造工艺和材料用于每一种类型的阐述，然后由进一步的发展和制造技术的最新进展和新的设计和能力的审查。该综述最后讨论了制造工艺开发的潜在未来方向，以实现在自由移动的动物中进行大规模高密度全脑慢性记录的长期目标。
Electrophysiological recording and stimulation of neuron activities are important for us to understand the function and dysfunction of the nervous system. To record/stimulate neuron activities as voltage fluctuation extracellularly, microelectrode array (MEA) implants are a promising tool to provide high temporal and spatial resolution for neuroscience studies and medical treatments. The design configuration and recording capabilities of the MEAs have evolved dramatically since their invention and manufacturing process development has been a key driving force for such advancement. Over the past decade, since the White House Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative launched in 2013, advanced manufacturing processes have enabled advanced MEAs with increased channel count and density, access to more brain areas, more reliable chronic performance, as well as minimal invasiveness and tissue reaction. In this state-of-the-art review paper, three major types of electrophysiological recording MEAs widely used nowadays, namely, microwire-based, silicon-based, and flexible MEAs are introduced and discussed. Conventional design and manufacturing processes and materials used for each type are elaborated, followed by a review of further development and recent advances in manufacturing technologies and the enabling new designs and capabilities. The review concludes with a discussion on potential future directions of manufacturing process development to enable the long-term goal of large-scale high-density brain-wide chronic recordings in freely moving animals.