Comparative studies on viscosity and concentration of protein and hexosamine in pure pancreatic juice
Comparative studies on viscosity and concentration of protein and hexosamine in pure pancreatic juice
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纯胰液中蛋白质和己糖胺粘度和浓度的比较研究
DOI：
10.1007/bf02813799
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
M. Komazawa
中科院分区：
文献类型：
--
作者：
H. Harada;O. Ueda;F. Kochi;Tomoko Kobayashi;M. Komazawa
为探讨慢性胰腺炎患者胰液粘度增高的原因，我们对纯胰液中蛋白质、氨基己糖、三种水解酶（淀粉酶、胰凝乳蛋白酶原和脂肪酶）、钙和γ-谷氨酰转肽酶的粘度和浓度进行了比较研究。纯胰液（PPJ）获得7个对照组，10例可能的慢性胰腺炎和6例明确的慢性胰腺炎通过内镜逆行导管乳头。在最初的4分钟内，在快速静脉注射促胰液素后，在20分钟内每隔2分钟将标本收集在冰冷的试管中（Pancreai Secrepan，1 U/kg体重），然后在快速静脉内注射胰酶素后以1分钟间隔持续10分钟结果表明，PPJ的粘度与水解酶蛋白、氨基己糖的浓度以及粘液物质和蛋白栓的存在密切相关。
In order to investigate the cause of an increase in viscosity of pancreatic juice in patients with chronic pancreatitis, we performed comparative studies on voscosity and concentration of protein, hexosamine, three hydrolytic enzymes (amylase, chymotrypsinogen and lipase), calcium and gamma-Glutamyltranspeptidase in pure pancreatic juice. Pure pancreatic juice (PPJ) was obtained from seven control subjects, 10 patients with probable chronic pancreatitis and six patients with definite chronic pancreatitis by means of endoscopic retrograde catheterization of the papilla. Specimens were collected in ice-cooled tubes during the initial four-minute period and thereafter at two-minute intervals for 20 minutes after a rapid intravenous injection of secretin (Eisai Secrepan, 1 U/kg of body weight) and then at one-minute intervals for 10 minutes after a rapid intravenous injection of pancreozymin (Boots, 1 U/kg of body weight).It was demonstrated that the viscosity of PPJ was closely related to the concentration of hydrolytic enzyme protein, hexosamine and the presence of mucous substance and protein plugs.