Manufactured RBC--rivers of blood, or an oasis in the desert?
Manufactured RBC--rivers of blood, or an oasis in the desert?
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DOI：
10.1016/j.biotechadv.2011.05.002
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发表时间：
2011-11
影响因子：
16
通讯作者：
Nicholas E. Timmins;Lars K. Nielsen
中科院分区：
文献类型：
--
作者：
Nicholas E. Timmins;Lars K. Nielsen
红细胞（RBC）输注是现代医学中的一项基本实践，完全依赖于供体血液的可用性。捐献者供应的限制导致了可输血红细胞可以从干细胞中制造的建议。虽然可以在体外产生少量的RBC，但需要非常大量的细胞才具有临床意义。我们探讨了大规模制造RBC所面临的挑战，以及实现这种情况所需的技术发展。
Red blood cell (RBC) transfusion is an essential practice in modern medicine, one that is entirely dependent on the availability of donor blood. Constraints in donor supply have led to proposals that transfusible RBC could be manufactured from stem cells. While it is possible to generate small amounts of RBC in vitro, very large numbers of cells are required to be of clinical significance. We explore the challenges facing large scale manufacture of RBC and technological developments required for such a scenario to be realised.