Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo
Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo
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白癜风患者CXCR3及其配体表达增加，CXCL10作为白癜风的潜在临床标志物
DOI：
10.1111/bjd.14416
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发表时间：
2016-06-01
影响因子：
10.3
通讯作者：
Xiang, L. H.
中科院分区：
文献类型：
--
作者：
Wang, X. X.;Wang, Q. Q.;Xiang, L. H.
白癜风是一种以表皮黑素细胞丢失为特征的皮肤病。最近的一项研究报道，CXCL10在白癜风小鼠模型中对色素脱失的进展和维持至关重要，但关于这一问题的临床数据非常有限，对于这些趋化因子在整个病程中的动态变化或与疾病严重程度的相关性知之甚少。
Vitiligo is a skin disorder characterized by loss of melanocytes from the epidermis. A recent study reported that CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo, but there is very limited clinical data regarding this issue and little is known about the dynamic changes or correlations with disease severity of these chemokines throughout the disease course.