Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates.

Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates.
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DOI:
10.1186/1759-8753-2-8
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发表时间:
2011-05-31
期刊:
影响因子:
4.9
通讯作者:
Greene WK
Greene WK
中科院分区:
生物学3区
文献类型:
--
作者:
Oliver KR;Greene WK

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转座元件(TES)越来越被认为是强大的进化促进剂。我们提出TE推力假说,以包含TE促进的过程,通过这些过程,基因组自我工程编码、调节、核型或其他遗传变化。虽然TES偶尔会对某些个体造成伤害,但TES引起的基因组活力对血统非常有利。这可能导致不同血统的存活率和繁殖力不同。具有丰富和合适的TES谱系的谱系具有增强的进化潜力,并且在其他条件相同的情况下,往往是多产的,导致物种丰富的适应性辐射,和/或它们往往经历重大的进化转变。基因组变化的许多其他机制在进化中也很重要,TE-冲的进化潜力是否实现在很大程度上取决于环境和生态因素。TES对进化创新的巨大贡献在灵长类谱系中得到了特别好的记录。在这篇文章中,我们回顾了许多由TE引起的对高等灵长类基因组有益的修改案例,这些案例有力地支持了我们的TE推力假说。
Transposable elements (TEs) are increasingly being recognized as powerful facilitators of evolution. We propose the TE-Thrust hypothesis to encompass TE-facilitated processes by which genomes self-engineer coding, regulatory, karyotypic or other genetic changes. Although TEs are occasionally harmful to some individuals, genomic dynamism caused by TEs can be very beneficial to lineages. This can result in differential survival and differential fecundity of lineages. Lineages with an abundant and suitable repertoire of TEs have enhanced evolutionary potential and, if all else is equal, tend to be fecund, resulting in species-rich adaptive radiations, and/or they tend to undergo major evolutionary transitions. Many other mechanisms of genomic change are also important in evolution, and whether the evolutionary potential of TE-Thrust is realized is heavily dependent on environmental and ecological factors. The large contribution of TEs to evolutionary innovation is particularly well documented in the primate lineage. In this paper, we review numerous cases of beneficial TE-caused modifications to the genomes of higher primates, which strongly support our TE-Thrust hypothesis.
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