RHEUMATOID-ARTHRITIS AS A RISK FACTOR FOR MULTIPLE-MYELOMA - A CASE CONTROL STUDY
RHEUMATOID-ARTHRITIS AS A RISK FACTOR FOR MULTIPLE-MYELOMA - A CASE CONTROL STUDY
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DOI：
10.1016/0959-8049(93)90188-l
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发表时间：
1993-01-01
影响因子：
8.4
通讯作者：
ERIKSSON, M
中科院分区：
文献类型：
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作者：
ERIKSSON, M
这项基于人群的病例对照调查旨在研究类风湿性关节炎、其他疾病和不同类型的治疗对发生多发性骨髓瘤风险的重要性。瑞典北部总共 275 例确诊骨髓瘤病例与同样多的对照受试者进行了匹配。有关不同疾病、药物使用、诊断性 X 射线检查和放射治疗的信息是通过邮寄给所有活着的受试者（即病例和对照）以及已故受试者的近亲的广泛调查问卷获得的。该研究证实了其与一般风湿性疾病和类风湿性关节炎之间的可疑关联。没有其他疾病会增加患骨髓瘤的风险，但相反，其他疾病在对照组中通常更常见。根据这一发现，病例中药物的使用和诊断性 X 射线检查也比对照组少见。然而，这项研究确实为最近的一项发现提供了一些支持，即 X 射线检查的数量可能是骨髓瘤的危险因素。在本研究中，良性适应症的早期放疗在病例中更为常见，而恶性疾病的放疗在对照组中更为常见。
This population-based case-control investigation was designed to study the importance of rheumatoid arthritis, other diseases and different types of treatment for the risk of developing multiple myeloma. In total, 275 cases with verified myeloma in northern Sweden were matched to as many control subjects. Information about different diseases, drug use, diagnostic X-ray investigations and radiotherapy was obtained through an extensive questionnaire mailed to all living subjects, i.e. cases and controls, and to the next of kin regarding deceased subjects. The study confirmed a suspected association with both rheumatic diseases in general and rheumatoid arthritis specifically. No other disease gave an increased risk for myeloma, but on the contrary, other diseases were in general more common among the controls. In accordance with this finding, use of medications and diagnostic X-ray investigations were also less common in cases than in controls. The study did, however, give some support to a recent finding that the number of X-ray investigations might be a risk factor for myeloma. Earlier radiotherapy on benign indications was more common in cases, whereas radiotherapy for malignant disease was more common among controls in this study.