TRANSFER OF FUNCTION TO A SPECIFIC AREA OF THE CORTEX AFTER INDUCED RECOVERY FROM BRAIN-DAMAGE
TRANSFER OF FUNCTION TO A SPECIFIC AREA OF THE CORTEX AFTER INDUCED RECOVERY FROM BRAIN-DAMAGE
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DOI：
10.1111/j.1460-9568.1992.tb00195.x
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发表时间：
1992-09-01
影响因子：
3.4
通讯作者：
BORRELL, J
中科院分区：
文献类型：
--
作者：
CASTROALAMANCOS, MA;GARCIASEGURA, LM;BORRELL, J
已经提出了诱导脑损伤后恢复的不同方法和可能介导诱导恢复的不同机制。一种可能的机制涉及大脑的一部分接管另一部分功能的能力。我们在这里表明，（1）当动物在行为任务的执行过程中根据适当的反应在大脑腹侧被盖核中接受颅内电刺激时，大鼠消除厌恶刺激的压杆行为得到恢复，该行为在额叶初级运动感觉皮层的双侧损伤后显著受损，（2）与未恢复的动物相比，在恢复的动物中，后部初级运动感觉皮层（后肢运动感觉皮层）中的区域显示fos样免疫反应性细胞的数量增加了35%，和（3）恢复的动物中该区域的双侧损伤恢复了行为任务表现的损伤。这些结果表明，大脑皮层的一个区域能够在诱导脑损伤恢复后承担另一个区域的作用。
Different methods of inducing recovery after brain damage and different mechanisms that might mediate the induced recovery have been proposed. One possible mechanism involves the ability of one part of the brain to take over the function of another. We show here in rats that (1) bar-pressing behaviour to eliminate an aversive stimulus, which becomes dramatically impaired after bilateral lesion of the frontal primary motor - sensory cortex, is recovered when the animals receive an electrical intracranial stimulation in the ventral tegmental nucleus of the brain contingent on an adequate response during performance in the behavioural task, (2) in recovered animals an area in the posterior primary motor-sensory cortex, the hindlimb motor-sensory cortex, shows a 35% increase in the number of fos-like immunoreactive cells compared to non-recovered animals, and (3) a bilateral lesion of this area in recovered animals reinstates the impairment in the performance of the behavioural task. These results indicate that an area of the cerebral cortex is able to assume the role of another area after induced recovery from brain damage.