Therapeutic Applications of Encapsulated Cells
Therapeutic Applications of Encapsulated Cells
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DOI：
10.1007/978-1-62703-550-7_23
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Maria Hernandez, Rosa
中科院分区：
文献类型：
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作者：
Acarregui, Argia;Orive, Gorka;Maria Hernandez, Rosa
细胞治疗和生物材料领域的一些有希望的进展与用于药物递送的更精细和定制的微胶囊的制造的改进一起的协同作用引发了细胞包封技术的进步。细胞微囊化涉及将移植的细胞固定在由膜包围的生物相容性支架内，以试图将细胞与宿主免疫攻击隔离并增强或延长其体内功能。该技术代表了一种策略，其目的在于克服与药物和生长因子的局部和全身控制释放以及与器官移植排斥相关的现有困难，因此需要使用免疫调节方案或免疫抑制药物。本章概述了细胞包封技术作为一种药物控释系统的现状，并强调了该技术的基本要求，一些治疗应用，挑战和未来的研究方向。
The synergy of some promising advances in the fields of cell therapy and biomaterials together with improvements in the fabrication of more refined and tailored microcapsules for drug delivery have triggered the progress of cell encapsulation technology. Cell microencapsulation involves immobilizing the transplanted cells within a biocompatible scaffold surrounded by a membrane in attempt to isolate the cells from the host immune attack and enhance or prolong their function in vivo. This technology represents one strategy which aims to overcome the present difficulties related to local and systemic controlled release of drugs and growth factors as well as to organ graft rejection and thus the requirements for use of immunomodulatory protocols or immunosuppressive drugs. This chapter gives an overview of the current situation of cell encapsulation technology as a controlled drug delivery system, and the essential requirements of the technology, some of the therapeutic applications, the challenges, and the future directions under investigation are highlighted.