Tumorigenic potential of a myc-containing strain of feline leukemia virus in vivo in domestic cats.
Tumorigenic potential of a myc-containing strain of feline leukemia virus in vivo in domestic cats.
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含有 myc 的猫白血病病毒株在家猫体内的致瘤潜力。
DOI：
10.1128/jvi.62.12.4770-4773.1988
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发表时间：
1988
影响因子：
5.4
通讯作者：
Baskin,GB
中科院分区：
文献类型：
--
作者：
Levy,LS;Fish,RE;Baskin,GB
将猫白血病病毒（FeLV）的含myc病毒株（称为LC-FeLV）接种到新生小猫体内后，检查了其致癌能力。与其他含myc的FeLV毒株一样，LC-FeLV可能在病毒血症动物中诱导（但不一定诱导）胸腺淋巴肉瘤，潜伏期相对较短。自然发生和实验诱导的肿瘤是T细胞淋巴瘤，其含有克隆整合的LC-FeLV前病毒DNA，并且在存在或不存在外源性白细胞介素-2的情况下不易于体外培养。FeLV获得myc可缩短肿瘤出现前的潜伏期，但不会扩大FeLV单独诱导的肿瘤谱。
The oncogenic capacity of a myc-containing strain of feline leukemia virus (FeLV), termed LC-FeLV, has been examined after inoculation of the virus into neonatal kittens. Like other myc-containing strains of FeLV, LC-FeLV may induce with relatively short latency, but does not necessarily induce, thymic lymphosarcoma in viremic animals. Naturally occurring and experimentally induced tumors are T-cell lymphomas which contain clonally integrated LC-FeLV proviral DNA and which cannot readily be cultivated in vitro in the presence or absence of exogenously supplied interleukin-2. Acquisition of myc by FeLV decreases the period of latency before the appearance of tumors but does not expand the spectrum of tumors induced by FeLV alone.