MIIP expression predicts outcomes of surgically resected esophageal squamous cell carcinomas
MIIP expression predicts outcomes of surgically resected esophageal squamous cell carcinomas
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MIIP 表达预测食管鳞状细胞癌手术切除的结果
DOI：
10.1007/s13277-015-4633-2
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发表时间：
2016-08-01
期刊：
影响因子：
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通讯作者：
Fu, Jian-Hua
中科院分区：
文献类型：
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作者：
Wen, Jing;Liu, Qian-Wen;Fu, Jian-Hua
迁移和侵袭抑制蛋白（MIIP）被证明是胶质瘤中的肿瘤抑制基因，通过抑制肿瘤细胞的生长、迁移和侵袭。然而，其在食管鳞状细胞癌（ESCC）中的作用和临床意义尚未阐明。我们研究了一组手术切除的食管鳞癌中MIIP表达与临床结果的相关性。采用免疫组化方法对253例手术切除的ESCC原发性肿瘤和癌旁正常食管上皮的组织微阵列进行MIIP评价。统计分析MIIP表达的临床意义和预后意义。癌组织中MIIP的表达明显高于癌旁正常组织（P< 0.001）。MIIP表达与食管鳞癌细胞分化程度有关（P <0.001）。Kaplan-Meier分析显示，MIIP低表达患者的总生存期（OS）和无病生存期（DFS）较MIIP高表达患者明显改善（P = 0.039和0.086）。此外，MIIP表达可区分T3-4期（P= 0.020，0.028）、N 0期（P= 0.008，0.032）和II期（P= 0.004，0.019）以及胸下段食管肿瘤患者的OS或DFS（P= 0.024，0.090）。多因素分析显示MIIP表达是影响食管鳞癌OS和DFS的独立预后因素。总之，MIIP在食管鳞癌中的表达高于癌旁正常食管上皮，是一个积极的，独立的预后因素。
The migration and invasion inhibitory protein (MIIP) was shown to function as a tumor suppressor gene in gliomas by inhibiting tumor cell growth, migration, and invasion. However, its role and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been elucidated. We investigated the correlation of MIIP expression and clinical outcome in a group of surgically resected ESCCs. Tissue microarrays constructed of 253 surgically resected ESCC primary tumors and paired paracancerous normal esophageal epithelia were used for MIIP evaluation by immunohistochemistry. The clinical and prognostic significance of MIIP expression was analyzed statistically. The expression of MIIP expression in cancer tissues was increased significantly in comparison with the paired paracancerous normal epithelia (P< 0.001). And, MIIP expression was associated with ESCC cells’ differentiation (P <0.001). By Kaplan-Meier analysis, patients with low MIIP expression exhibited significantly improved overall survival (OS,P= 0.039) and a tendency of improved disease-free survival (DFS,P= 0.086) than those with high MIIP expression. In addition, MIIP expression could distinguish OS or DFS of patients with tumors in stage T3–4 (P= 0.020, 0.028), N0 (P= 0.008, 0.032), and stage II (P= 0.004, 0.019), as well as at lower thoracic esophagus (P= 0.024, 0.090). Multivariate analysis showed that MIIP expression was an independent prognostic factor in ESCC OS and DFS. In conclusion, MIIP expressed higher in ESCCs than in paracancerous normal esophageal epithelia and was a positive, independent prognostic factor in resected ESCCs.