Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions
Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions
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DOI：
10.1182/blood.v96.4.1599.h8001599_1599_1601
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发表时间：
2000-08-15
期刊：
影响因子：
20.3
通讯作者：
Tosato, G
中科院分区：
文献类型：
--
作者：
Aoki, Y;Yarchoan, R;Tosato, G
卡波西肉瘤相关疱疹病毒编码病毒IL-6 （vIL-6）。为了探讨vIL-6在人类免疫缺陷病毒（HIV）相关原发性积液淋巴瘤（PEL）发病机制中的潜在作用，建立了一种针对vIL-6的灵敏酶联免疫吸附试验，并将其应用于PEL的研究。8例PEL积液中有6例可检测到IL-6（范围1390-66 630 pg/mL），而在任何对照积液中均未检测到IL-6。正如预期的那样，所有PEL积液均含有人IL-6（范围957-37 494 pg/mL）， 8例中有7例含有可检测的人IL-10（范围66-2,521,297 pg/mL），人类和IL-6先前已被证明可诱导血管内皮生长因子，从而增加血管通透性。目前的研究结果表明，这些细胞因子在PEL的发病机制和表现中起着核心作用。（血液。2000;96:1599-1601）(C) 2000由美国血液学会。
Kaposi sarcoma-associated herpesvirus encodes Viral IL-6 (vIL-6). To investigate the potential role of vIL-6 in the pathogenesis of human immunodeficiency virus (HIV)related primary effusion lymphomas (PEL), a sensitive enzyme-linked immunosorbent assay was developed for vIL-6 and applied to the study of PEL. Whereas vIL-6 was detectable in 6 of 8 PEL effusions (range, 1390-66 630 pg/mL), it was not detectable in any of the control effusions, As expected, all PEL effusions contained human IL-6 (range, 957-37 494 pg/mL), and 7 of 8 contained detectable human IL-10 (range, 66-2,521,297 pg/mL), Human and vIL-6 have previously been shown to induce vascular endothelial growth factor, which in turn can increase vascular permeability. The results of the current study suggest that these cytokines play a central role in the pathogenesis and manifestations of PEL. (Blood. 2000;96: 1599-1601) (C) 2000 by The American Society of Hematology.