Subclinical motor impairment assessed with an engineered glove correlates with magnetic resonance imaging tissue damage in radiologically isolated syndrome
Subclinical motor impairment assessed with an engineered glove correlates with magnetic resonance imaging tissue damage in radiologically isolated syndrome
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DOI：
10.1111/ene.13789
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发表时间：
2019-01-01
影响因子：
5.1
通讯作者：
De Stefano, N.
中科院分区：
文献类型：
--
作者：
Bonzano, L.;Bove, M.;De Stefano, N.
一种测量手指运动性能的工程手套先前显示出区分早期多发性硬化症（MS）患者和健康对照（HC）的能力。放射学孤立综合征（RIS）分类无症状受试者与脑磁共振成像（MRI）异常提示多发性sclerosis.Methods 17例无症状受试者与RIS和17 HC进行了评估。他们以最大速度进行手指对拇指对掌序列，节拍器起搏双手运动，常规和扩散张量MRI。结果RIS患者的最大速度低于HC患者（P = 0.005），双手协调功能障碍高于HC患者（P = 0.006）。在RIS中，双手协调与T2病变体积，分数各向异性和径向扩散率在白色matter.Conclusions这些研究结果指出了相关的精细的手措施作为一个强大的标记亚临床残疾。
Background An engineered glove measuring finger motor performance previously showed ability to discriminate early-stage multiple sclerosis (MS) patients from healthy controls (HCs). Radiologically isolated syndrome (RIS) classifies asymptomatic subjects with brain magnetic resonance imaging (MRI) abnormalities suggestive of multiple sclerosis.Methods Seventeen asymptomatic subjects with RIS and 17 HCs were assessed. They performed finger-to-thumb opposition sequences at their maximal velocity, metronome-paced bimanual movements and conventional and diffusion tensor MRI. Results Subjects with RIS showed lower (P = 0.005) maximal velocity and higher (P = 0.006) bimanual coordination impairment than HCs. In RIS, bimanual coordination correlated with T2-lesion volume, fractional anisotropy and radial diffusivity in the white matter.Conclusions These findings point out the relevance of fine hand measures as a robust marker of subclinical disability.