Noninvasive measurement of the hydrostatic pressure in a fluid-filled cavity based on the disappearance time of micrometer-sized free gas bubbles
Noninvasive measurement of the hydrostatic pressure in a fluid-filled cavity based on the disappearance time of micrometer-sized free gas bubbles
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DOI：
10.1016/s0301-5629(99)00109-x
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发表时间：
1999-11-01
影响因子：
2.9
通讯作者：
Bom, N
中科院分区：
文献类型：
--
作者：
Bouakaz, A;Frinking, PJA;Bom, N
本文介绍了一种基于微米级自由气泡消失时间的无创压力测量新方法。超声造影剂由封装的气泡组成，用作载体，将自由气泡输送到需要测量压力的区域。小的自由气泡在感兴趣的区域（例如，心室）产生，由被封装的气泡产生，当它们暴露于单个低频（例如，0.5 MHz），高声波振幅的美国爆发时破裂。释放的气泡仅持续几毫秒并溶解在液体中，具体时间取决于气泡的大小、气体、液体特性以及温度、气体浓度和压力等环境参数。压力消失时间关系是使用一系列高频（例如，10 MHz），低声波振幅的美国脉冲来确定的。在体外实验中，可重复性的结果表明，气泡的消失时间随局部压力的变化有显著差异，压力越大，气泡的消失速度越快。证明了该方法对小的压力变化（50 mmHg）的灵敏度。(C) 1999年世界超声医学和生物学联合会。
A new method for noninvasive pressure measurement, based on the disappearance time of micrometer-sized free gas bubbles, is described in this article. An ultrasound (US) contrast agent, consisting of encapsulated gas bubbles, is used as a vehicle to transport the free gas bubbles to the desired region where the pressure is to be measured. The small free gas bubbles are generated at the region of interest (e.g., heart chambers), from the encapsulated gas bubbles, which rupture when they are exposed to a single low-frequency (e.g., 0.5 MHz), high acoustic amplitude US burst. The released gas bubbles persist for only a few ms and dissolve in the liquid, depending on their size, the gas, the liquid characteristics and ambient parameters such as temperature, gas concentration and pressure. A pressure-disappearance time relationship is determined using a sequence of high-frequency (e.g., 10 MHz), low acoustic amplitude US pulses. From in vitro experiments, reproducible results show a significant difference between the disappearance time of the bubbles as function of the local pressure, resulting in a quicker disappearance of the bubble for higher values of the pressure. The sensitivity of the method to small pressure changes (50 mmHg) is demonstrated. (C) 1999 World Federation for Ultrasound in Medicine & Biology.