Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells
Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells
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BEL7402 肝癌细胞获得失巢凋亡抗性揭示了类似 Synoikis 的生存方式
DOI：
10.1016/j.canlet.2008.03.010
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发表时间：
2008-08-18
期刊：
影响因子：
9.7
通讯作者：
Sun, Wensheng
中科院分区：
文献类型：
--
作者：
Zhang, Zhiyong;Cao, Lill;Sun, Wensheng
对失巢凋亡的抵抗是人类恶性肿瘤的标志。我们的研究结果表明，肝癌细胞抗失巢凋亡的机制是不增殖、不凋亡和细胞周期阻滞，即类滑膜细胞凋亡。这些滑膜样细胞对细胞外刺激具有更强的抵抗力，并且在适当的条件下可以自发地附着并再次增殖，这表明这些细胞具有可逆性。基因芯片表达谱揭示了滑膜细胞样肝癌细胞中相关分子的变化，我们的数据表明ANGPTL4有助于肝癌细胞的抗失巢凋亡。这些结果表明，肝癌细胞可能通过类滑膜细胞凋亡的生存方式抵抗失巢凋亡，这可能有助于肿瘤转移。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and proliferate again under suitable conditions, which indicate a reversible property of these cells. Microarray expression profile reveals the change of molecules involved in the synoikis-like hepatoma cells and our data indicated that ANGPTL4 contributed to anoikis resistance of hepatoma cells. These results demonstrated that hepatoma cells might resist anoikis through a synoikis-like survival style, which may facilitate tumor metastasis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.