Fourier domain Pump-Probe Optical Coherence Tomography imaging of melanin.
Fourier domain Pump-Probe Optical Coherence Tomography imaging of melanin.
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DOI：
10.1364/oe.18.012399
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发表时间：
2010-06-07
期刊：
影响因子：
3.8
通讯作者：
Applegate BE
中科院分区：
文献类型：
--
作者：
Jacob D;Shelton RL;Applegate BE
We report the development of a two-color Fourier domain Pump-Probe Optical Coherence Tomography (PPOCT) system. Tissue phantom experiments to characterize the system performance demonstrated imaging depths in excess of 725 μm, nearly comparable to the base Optical Coherence Tomography system. PPOCT A-line rates were also demonstrated in excess of 1 kHz. The physical origin of the PPOCT signal was investigated with a series of experiments which revealed that the signal is a mixture of short and long lifetime component signals. The short lifetime component was attributed to transient absorption while the long lifetime component may be due to a mixture of transient absorption and thermal effects. Ex vivo images of porcine iris demonstrated the potential for imaging melanin in the eye, where cancer of the melanocytes is the most common form of eye cancer in adults.
