Photodynamic therapy: Tumor volume limitation and tumor response for murine fibrosarcoma
Photodynamic therapy: Tumor volume limitation and tumor response for murine fibrosarcoma
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光动力疗法：小鼠纤维肉瘤的肿瘤体积限制和肿瘤反应
DOI：
10.1002/lsm.1900100209
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发表时间：
1990
影响因子：
2.4
通讯作者：
F. Al
中科院分区：
文献类型：
--
作者：
F. Al
使用C3 H小鼠作为动物模型，研究了光动力疗法（PDT）后RIF-1的克隆形成存活率和肿瘤生长与肿瘤体积的关系。克隆形成存活率显示对于大体积（大于1，900 mm 3）接近99.8%存活率的饱和水平，这可能表明由于有限的组织穿透和/或肿瘤缺氧，630 nm的光利用率差。对于小肿瘤体积[<150 mm 3]，存活率（<0.3%）随体积呈指数增加。对应于体积低于50 mm 3的生存率（<0.03%）可以完全根除肿瘤。另一方面，体积大于90 mm 3时观察到部分缓解和复发，其生存率超过0.1%。PDT后，所有肿瘤均立即肿胀和皮肤变色，随后坏死，肿瘤延迟和再生。再生长速率和肿瘤细胞倍增时间比对照生长慢，并在第二次间质照明的浅表照射后进一步降低。对于小的初始肿瘤体积，再生长速率慢，而对于大的初始肿瘤体积，再生长速率快。此外，与中等肿瘤体积的较短时间相比，小初始肿瘤体积的延迟时间较长，而大体积的延迟概率非常低。
The clonogenic survival rates and tumor growths following photodynamic therapy (PDT) were studied as a function of tumor volume for RIF‐1 using C3H mice as an animal model. The clonogenic survival rates showed a saturation level approaching a 99.8% survival rate for large volumes (above 1,900 mm3), possibly indicating poor light utilization of 630 nm because of the limited tissue penetration and/or tumor hypoxia. With a small tumor volume [<150 mm3], the survival rate (<0.3%) showed an exponential increase with volume. The survival rates (<0.03%) corresponding to a volume lower than 50 mm3 gave complete tumor eradication. On the other hand, partial response and recurrence were noticed with volumes larger than 90 mm3, which had more than ∼0.1% survival rates. After PDT, all tumors responded with immediate swelling and skin discoloration, followed by necrosis, tumor delay, and regrowth. Regrowth rate and tumor cell doubling time were slower than the control growths and decreased further following superficial irradiation with a second interstitial illumination. The regrowth rates were slow for small initial tumor volumes and fast for large initial tumor volumes. Also, the delay period was longer for the small initial tumor volumes in comparison to a shorter period for the medium tumor volumes and very low probability of delay for the large volumes.
影响因子：
11.2
作者：
B. Henderson;S. Waldow;T. Mang;W. Potter;P. B. Malone;T. Dougherty
通讯作者：
B. Henderson;S. Waldow;T. Mang;W. Potter;P. B. Malone;T. Dougherty