Fatty acid composition of umbilical arteries and veins: possible implications for the fetal EFA-status.
Fatty acid composition of umbilical arteries and veins: possible implications for the fetal EFA-status.
复制标题
脐动脉和静脉的脂肪酸组成：对胎儿 EFA 状态的可能影响。
作者：
Hornstra,G;vanHouwelingen,AC;Simonis,M;Gerrard,JM
测定从荷兰新生儿阴道分娩、终止正常妊娠后的脐动脉和静脉中分离出的磷脂的脂肪酸组成。脐带血管的脂肪酸谱的特点是缺乏二十碳五烯酸（timnodonic），亚油酸含量低（2-3%），以及适量的花生四烯酸（10-15%）和二十二碳六烯酸（cervonic）（3-5%）。还观察到大量的米德酸 (1–4%) 及其直接伸长产物 (0.5–2%)。在每根脊髓中，传出血管比传入血管含有明显更多的米德酸和其他油酸（n−9）家族脂肪酸，以及更少的亚油酸（n−6）和亚麻酸（n−3）家族脂肪酸。这表明“下游”新生儿组织的必需脂肪酸（EFA）状态可能处于边缘状态。在培养的内皮细胞和平滑肌细胞或成人血管中没有观察到EFA缺乏的迹象。在所有脊髓中，与静脉相比，动脉中的 22∶5(n−6) 显着较高，而对于所有其他 (n−6) 脂肪酸，这种差异为负。由于已知当所需的牛酸量 22∶6(n−3) 太低时，22∶5(n−6) 的合成会受到刺激，因此我们的观察结果还表明，所研究的新生儿的牛酸状态并非最佳。进一步的研究正在进行中，以将这些发现与母亲的全民教育状况和妊娠并发症联系起来。
Fatty acid compositions were determined of phospholipids, isolated from umbilical arteries and veins, obtained from Dutch neonates after vaginal delivery, terminating normal pregnancy. The fatty acid profiles of the cord vessels were characterized by the absence of eicosapentaenoic (timnodonic) acid, a low (2–3%) content of linoleic acid and reasonable amounts of arachidonic acid (10–15%) and docosahexaenoic (cervonic) acid (3–5%). Significant amounts of Mead acid (1–4%) and its direct elongation product (0.5–2%) were also observed. In each cord, the efferent blood vessels contained significantly more Mead acid and other fatty acids of the oleic acid (n−9) family and less fatty acids of the linoleic (n−6) and linolenic (n−3) families than the afferent blood vessel. This indicates that the essential fatty acid (EFA) status of ‘downstream’ neonatal tissue may be marginal. No signs of EFA-deficiency were observed in endothelial and smooth muscle cells in culture, or in blood vessels from adults. In all cords 22∶5(n−6) was significantly higher in the artery compared to the vein, whereas for all other (n−6) fatty acids this difference was negative. Since the synthesis of 22∶5(n−6) is known to be stimulated when the required amount of cervonic acid, 22∶6(n−3), is too low, our observations also suggest that the cervonic acid status of the neonates investigated was not optimal. Further studies are in progress to relate these findings to maternal EFA status and complications of pregnancy.