A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia
A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia
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DOI：
10.1016/j.bandl.2019.04.006
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发表时间：
2019-07-01
影响因子：
2.5
通讯作者：
Grossman, Murray
中科院分区：
文献类型：
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作者：
Ash, Sharon;Nevler, Naomi;Grossman, Murray
我们研究了48例原发性进行性失语症（PPA）或行为变异性额颞叶痴呆（bvFTD）患者在半结构化语音样本中语言表达的纵向变化，并将其与其中25例患者的皮质厚度纵向神经成像相关。所有患者组的言语流利性和语法指标均显著下降，但非流利/语法不通PPA（naPPA）患者的下降程度大于语义变体、逻辑缺失变体和bvFTD患者。这些患者组在几项神经心理学指标上也有所下降，但言语表达下降与神经心理学表现下降之间没有相关性。语法性的纵向下降，通过产生的格式良好的句子的数量进行评估，与左额叶盖/颞叶和双侧颞叶皮层的灰质萎缩的纵向进展相关。
We examined longitudinal change in language expression during a semi-structured speech sample in 48 patients with primary progressive aphasia (PPA) or behavioral variant frontotemporal dementia (bvFTD) and related this to longitudinal neuroimaging of cortical thickness available in 25 of these patients. All patient groups declined significantly on measures of both speech fluency and grammar, although patients with nonfluent/agrammatic PPA (naPPA) declined to a greater extent than patients with the semantic variant, the logopenic variant, and bvFTD. These patient groups also declined on several neuropsychological measures, but there was no correlation between decline in speech expression and decline in neuropsychological performance. Longitudinal decline in grammaticality, assessed by the number of well-formed sentences produced, was associated with longitudinal progression of gray matter atrophy in left frontal operculum/insula and bilateral temporal cortex.